Groundwater resources as a global reservoir for antimicrobial-resistant bacteria

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dc.contributor.authorAndrade, Luisa
dc.contributor.authorKelly, Madeleine
dc.contributor.authorHynds, Paul
dc.contributor.authorWeatherill, John
dc.contributor.authorMajury, Anna
dc.contributor.authorO'Dwyer, Jean
dc.contributor.funderSuirbhéireacht Gheolaíochta Éireannen
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderEuropean Regional Development Funden
dc.date.accessioned2020-01-08T11:44:12Z
dc.date.available2020-01-08T11:44:12Z
dc.date.issued2019-12-03
dc.date.updated2020-01-08T11:34:49Z
dc.description.abstractAntimicrobial resistance represents one of our most significant global health threats, with increasing incidences noted in both clinical and environmental settings. As such, identifying and understanding the sources and pathways for antimicrobial-resistant bacteria (ARB) is critical. The current study presents the first systematic review and pooled analysis of ARB occurrence in global groundwater supplies, which are used as primary drinking water sources by 2.2 billion people worldwide and are recurrently linked to significant outbreaks of infection. Seventy peer-reviewed studies were identified and included; findings reveal that 80.2% ± 29.0 and 57.2% ± 36.8 of aggregated groundwater isolates were resistant to ≥1 and ≥3 antimicrobials, respectively. Where bacteria were present, ARB were identified in 76.9% ± 33.7 of individual wells and springs. Our results leave little doubt that groundwater represents a major global reservoir for ARB, however significant research is required to establish environmental determinants and mechanisms mediating their occurrence.en
dc.description.sponsorshipScience Foundation Ireland (Irish Centre for Research in Applied Geosciences (iCRAG) Environmental Geosciences Postgraduate Programme)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid115360en
dc.identifier.citationAndrade, L., Kelly, M., Hynds, P., Weatherill, J., Majury, A. and O'Dwyer, J. (2019) 'Groundwater resources as a global reservoir for antimicrobial-resistant bacteria', Water Research, 170, 115360 (13pp). doi: 10.1016/j.watres.2019.115360en
dc.identifier.doi10.1016/j.watres.2019.115360en
dc.identifier.eissn1879-2448
dc.identifier.endpage13en
dc.identifier.issn0043-1354
dc.identifier.journaltitleWater Researchen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9459
dc.identifier.volume170en
dc.language.isoenen
dc.publisherElsevier Ltd.en
dc.rights© 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectGroundwateren
dc.subjectAntimicrobial resistanceen
dc.subjectDrinking wateren
dc.subjectEnvironment and healthen
dc.subjectRisk factorsen
dc.titleGroundwater resources as a global reservoir for antimicrobial-resistant bacteriaen
dc.typeArticle (peer-reviewed)en
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