A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: does maternal inflammation play a role?

Simple item page
dc.check.date2020-05-02
dc.check.infoAccess to this article is restricted until 18 months after publication by request of the publisher.en
dc.contributor.authorMaher, Gillian M.
dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.authorMcCarthy, Cathal M.
dc.contributor.authorKenny, Louise C.
dc.contributor.authorKearney, Patricia M.
dc.contributor.authorKhashan, Ali S.
dc.contributor.authorO'Keeffe, Gerard W.
dc.date.accessioned2018-11-23T11:37:26Z
dc.date.available2018-11-23T11:37:26Z
dc.date.issued2018-11-02
dc.date.updated2018-11-23T11:31:50Z
dc.description.abstractPre-eclampsia is a leading cause of maternal death and maternal and perinatal morbidity. Whilst the clinical manifestations of pre-eclampsia often occur in late pregnancy, the molecular events leading into the onset of this disease are thought to originate in early pregnancy and result in insufficient placentation. Although the causative molecular basis of pre-eclampsia remains poorly understood, maternal inflammation is recognised as a core clinical feature. While the adverse effects of pre-eclampsia on maternal and fetal health in pregnancy is well-recognised, the long-term impact of pre-eclampsia exposure on the risk of autism spectrum disorder (ASD) in exposed offspring is a topic of on-going debate. In particular, a recent systematic review has reported an association between exposure to pre-eclampsia and increased risk of ASD, however the molecular basis of this association is unknown. Here we review recent evidence for; 1) maternal inflammation in pre-eclampsia; 2) epidemiological evidence for alterations in neurodevelopmental outcomes in offspring exposed to pre-eclampsia; 3) long-term changes in the brains of offspring exposed to pre-eclampsia; and 4) how maternal inflammation may lead to altered neurodevelopmental outcomes in pre-eclampsia exposed offspring. Finally, we discuss the implications of this for the development of future studies in this field.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMaher, G. M., McCarthy, F. P., McCarthy, C. M., Kenny, L. C., Kearney, P. M., Khashan, A. S. and O'Keeffe, G. W. (2018) 'A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: does maternal inflammation play a role?', International Journal of Developmental Neuroscience. doi:10.1016/j.ijdevneu.2018.10.004en
dc.identifier.doi10.1016/j.ijdevneu.2018.10.004
dc.identifier.issn0736-5748
dc.identifier.journaltitleInternational Journal of Developmental Neuroscienceen
dc.identifier.urihttps://hdl.handle.net/10468/7137
dc.language.isoenen
dc.publisherElsevier Ltd.en
dc.rights© 2018, Elsevier B.V. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectPre-eclampsiaen
dc.subjectAutismen
dc.subjectBehaviouren
dc.subjectMaternalen
dc.subjectInflammationen
dc.subjectPlacentaen
dc.subjectCytokineen
dc.titleA perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: does maternal inflammation play a role?en
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Accepted_paper_CORA_GOK_23.11.2016.pdf
Size:
514.28 KB
Format:
Adobe Portable Document Format
Description:
Accepted Version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Public Health - Journal Articles
Anatomy and Neuroscience - Journal Articles
INFANT Research Centre - Journal Articles
Obstetrics & Gynaecology - Journal articles
Pharmacology and Therapeutics - Journal Articles