AllergoOncology: microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

dc.contributor.authorUntersmayr, Eva
dc.contributor.authorBax, Heather J.
dc.contributor.authorBergmann, Christoph
dc.contributor.authorBianchini, Rodolfo
dc.contributor.authorCozen, Wendy
dc.contributor.authorGould, Hannah J.
dc.contributor.authorHartmann, Karin
dc.contributor.authorJosephs, Debra H.
dc.contributor.authorLevi-Schaffer, Francesca
dc.contributor.authorPenichet, Manuel L.
dc.contributor.authorO'Mahony, Liam
dc.contributor.authorPoli, Aurelie
dc.contributor.authorRedegeld, Frank A.
dc.contributor.authorRoth-Walter, Franziska
dc.contributor.authorTurner, Michelle C.
dc.contributor.authorVangelista, Luca
dc.contributor.authorKaragiannis, Sophia N.
dc.contributor.authorJensen-Jarolim, Erika
dc.contributor.funderNational Institute for Health Researchen
dc.contributor.funderEuropean Academy of Allergy and Clinical Immunologyen
dc.contributor.funderFoundation for the National Institutes of Healthen
dc.contributor.funderDeutsche Forschungsgemeinschaften
dc.contributor.funderAimwell Charitable Trust and Emailie Gutterman Memorial Endowed Funden
dc.contributor.funderDepartament de Salut, Generalitat de Catalunyaen
dc.contributor.funderIGEM Therapeutics Ltden
dc.contributor.funderAustrian Science Funden
dc.contributor.funderInstytut Biologii Medycznej Polskiej Akademii Nauken
dc.contributor.funderCancer Research UKen
dc.contributor.funderMedical Research Councilen
dc.contributor.funderIsrael Science Foundationen
dc.contributor.funderIsrael Cancer Associationen
dc.contributor.funderAmerican Society of Hematologyen
dc.contributor.funderBreast Cancer Nowen
dc.contributor.funderStop Canceren
dc.contributor.funderIsrael Ministry of Science, Technology and Space “Personalized Medicine”en
dc.date.accessioned2019-10-06T21:30:53Z
dc.date.available2019-10-06T21:30:53Z
dc.date.issued2019-06-07
dc.description.abstractThe microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.en
dc.description.sponsorshipNational Institute for Health Research (Grant Number: IS‐BRC‐1215‐20006); Foundation for the National Institutes of Health (Grant Numbers: R01 CA181115, R01CA196266, R01CA196266‐01A1:S1, R03CA173842); Deutsche Forschungsgemeinschaft (Grant Number: HA 2393/6‐1); Departament de Salut, Generalitat de Catalunya (Grant Number: SLT002/16/00232); Austrian Science Fund (Grant Numbers: F4606‐B28, KLI284, P23398‐B11); Cancer Research UK (Grant Numbers: C30122/A11527, C30122/A15774); Israel Science Foundation (Grant Number: #213/05); Israel Cancer Association (Grant Number: #20161131); Breast Cancer Now (Grant Number: C10355/A15587); Israel Science Foundation “Center of Excellence /MOKED”;en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationUntersmayr, E., Bax, H. J., Bergmann, C., Bianchini, R., Cozen, W., Gould, H. J., Hartmann, K., Josephs, D. H., Levi-Schaffer, F., Penichet, M. L., O'Mahony, L., Poli, A., Redegeld, F. A., Roth-Walter, F., Turner, M. C., Vangelista, L., Karagiannis, S. N. and Jensen-Jarolim, E. (2019) 'AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper', Allergy, 74(6), pp.1037-1051. DOI: 10.1111/all.13718en
dc.identifier.doi10.1111/all.13718en
dc.identifier.endpage1051en
dc.identifier.issn0105-4538
dc.identifier.issued6en
dc.identifier.journaltitleAllergy: European Journal of Allergy and Clinical Immunologyen
dc.identifier.startpage1037en
dc.identifier.urihttps://hdl.handle.net/10468/8710
dc.identifier.volume74en
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectinfo:eu-repo/grantAgreement/RCUK/MRC/MR/L023091/1/GB/Preclinical efficacy of an antibody of the IgE class against a melanoma-associated antigen/en
dc.relation.urihttps://onlinelibrary.wiley.com/doi/full/10.1111/all.13718
dc.rights© 2019 The Authors. Allergy Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAllergyen
dc.subjectCanceren
dc.subjectHygience hypothesisen
dc.subjectMicrobiotaen
dc.subjectOncoimmunologyen
dc.titleAllergoOncology: microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paperen
dc.typeArticle (peer-reviewed)en
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