An altered gut microbiome in pre-eclampsia: cause or consequence

dc.contributor.authorDeady, Claraen
dc.contributor.authorMcCarthy, Fergus P.en
dc.contributor.authorBarron, Aaronen
dc.contributor.authorMcCarthy, Cathal M.en
dc.contributor.authorO'Keeffe, Gerard W.en
dc.contributor.authorO'Mahony, Siobhain M.en
dc.contributor.funderIrish Research Councilen
dc.date.accessioned2024-05-10T14:27:04Z
dc.date.available2024-05-10T14:27:04Z
dc.date.issued2024-05-07en
dc.description.abstractHypertensive disorders of pregnancy, including pre-eclampsia, are a leading cause of serious and debilitating complications that affect both the mother and the fetus. Despite the occurrence and the health implications of these disorders there is still relatively limited evidence on the molecular underpinnings of the pathophysiology. An area that has come to the fore with regard to its influence on health and disease is the microbiome. While there are several microbiome niches on and within the body, the distal end of the gut harbors the largest of these impacting on many different systems of the body including the central nervous system, the immune system, and the reproductive system. While the role of the microbiome in hypertensive disorders, including pre-eclampsia, has not been fully elucidated some studies have indicated that several of the symptoms of these disorders are linked to an altered gut microbiome. In this review, we examine both pre-eclampsia and microbiome literature to summarize the current knowledge on whether the microbiome drives the symptoms of pre-eclampsia or if the aberrant microbiome is a consequence of this condition. Despite the paucity of studies, obvious gut microbiome changes have been noted in women with pre-eclampsia and the individual symptoms associated with the condition. Yet further research is required to fully elucidate the role of the microbiome and the significance it plays in the development of the symptoms. Regardless of this, the literature highlights the potential for a microbiome targeted intervention such as dietary changes or prebiotic and probiotics to reduce the impact of some aspects of these disorders.en
dc.description.sponsorshipIrish Research Council (GOIPG/ 2022/426)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid1352267en
dc.identifier.citationDeady, C., McCarthy, F.P., Barron, A., McCarthy, C.M., O’Keeffe, G.W. and O’Mahony, S.M. (2024) ‘An altered gut microbiome in pre-eclampsia: cause or consequence’, Frontiers in Cellular and Infection Microbiology, 14, 1352267 (12 pp). Available at: https://doi.org/10.3389/fcimb.2024.1352267en
dc.identifier.doihttps://doi.org/10.3389/fcimb.2024.1352267en
dc.identifier.endpage12en
dc.identifier.issn2235-2988en
dc.identifier.journaltitleFrontiers in Cellular and Infection Microbiologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/15853
dc.identifier.volume14en
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.relation.ispartofFrontiers in Cellular and Infection Microbiologyen
dc.rights© 2024 Deady, McCarthy, Barron, McCarthy, O’Keeffe and O’Mahony. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectPre-eclampiaen
dc.subjectMicrobiomeen
dc.subjectInflammationen
dc.subjectProbioticsen
dc.subjectDiet-interventionen
dc.titleAn altered gut microbiome in pre-eclampsia: cause or consequenceen
dc.typeArticle (peer-reviewed)en
oaire.citation.volume14en
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