Development of a standardized chart review method to identify drug-related hospital admissions in older people

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dc.contributor.authorThevelin, Stefanie
dc.contributor.authorSpinewine, Anne
dc.contributor.authorBeuscart, Jean-Baptiste
dc.contributor.authorBoland, Benoît
dc.contributor.authorMarien, Sophie
dc.contributor.authorVaillant, Fanny
dc.contributor.authorWilting, Ingeborg
dc.contributor.authorVondeling, Ariel
dc.contributor.authorFloriani, Carmen
dc.contributor.authorSchneider, Claudio
dc.contributor.authorDonzé, Jacques
dc.contributor.authorRodondi, Nicolas
dc.contributor.authorCullinan, Shane
dc.contributor.authorO'Mahony, Denis
dc.contributor.authorDalleur, Olivia
dc.contributor.funderHorizon 2020en
dc.contributor.funderState Secretariat for Education, Research and Innovation, Switzerland
dc.date.accessioned2018-09-24T08:10:51Z
dc.date.available2018-09-24T08:10:51Z
dc.date.issued2018-07-14
dc.date.updated2018-09-21T11:44:24Z
dc.description.abstractAim: We aimed to develop a standardized chart review method to identify drug-related hospital admissions (DRA) in older people caused by non-preventable adverse drug reactions and preventable medication errors including overuse, underuse and misuse of medications: the DRA adjudication guide. Methods: The DRA adjudication guide was developed based on design and test iterations with international and multidisciplinary input in 4 subsequent steps: literature review, evaluation of content validity using a Delphi consensus technique, a pilot test and a reliability study. Results: The DRA adjudication guide provides definitions, examples and step-by-step instructions to measure DRA. A 3-step standardized chart review method was elaborated including 1) data abstraction, 2) explicit screening with a newly developed trigger tool for DRA in older people and 3) consensus adjudication for causality by a pharmacist and a physician using the World Health Organization-Uppsala Monitoring Centre and Hallas criteria. A 15-member international Delphi panel reached consensus agreement on 26 triggers for DRA in older people. The DRA adjudication guide showed good feasibility of use and achieved moderate inter-rater reliability for the evaluation of 16 cases by 4 European adjudication pairs (71% agreement, kappa = 0.41). Disagreements arose mainly for cases with potential underuse. Conclusions: The DRA adjudication guide is the first standardized chart review method to identify DRA in older persons. Content validity, feasibility of use and inter-rater reliability were found to be satisfactory. The method can be used as an outcome measure for interventions targeted at improving quality and safety of medication use in older people.en
dc.description.sponsorshipState Secretariat for Education, Research and Innovation, Switzerland (Contract Number 15.0137)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationThevelin, S., Spinewine, A., Beuscart, J.-B., Boland, B., Marien, S., Vaillant, F., Wilting, I., Vondeling, A., Floriani, C., Schneider, C.,Donzé J., Rodondi, N., Cullinan, S., O'Mahony, D. and Dalleur, O. (2018) 'Development of a standardized chart review method to identify drug-related hospital admissions in older people', British Journal of Clinical Pharmacology. doi: 10.1111/bcp.13716en
dc.identifier.doi10.1111/bcp.13716
dc.identifier.issn0306-5251
dc.identifier.issn1365-2125
dc.identifier.journaltitleBritish Journal of Clinical Pharmacologyen
dc.identifier.urihttps://hdl.handle.net/10468/6866
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc. on behalf of the British Pharmacological Societyen
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/634238/EU/OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly/OPERAMen
dc.rights© 2018, the British Pharmacological Society. Published by John Wiley & Sons, Inc. This is the peer reviewed version of the following article: Thevelin, S., Spinewine, A., Beuscart, J.-B., Boland, B., Marien, S., Vaillant, F., Wilting, I., Vondeling, A., Floriani, C., Schneider, C.,Donzé J., Rodondi, N., Cullinan, S., O'Mahony, D. and Dalleur, O. (2018) 'Development of a standardized chart review method to identify drug-related hospital admissions in older people', British Journal of Clinical Pharmacology. doi: 10.1111/bcp.13716, which has been published in final form at https://doi.org/10.1111/bcp.13716. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectElderlyen
dc.subjectGeriatricsen
dc.subjectMedication safetyen
dc.subjectClinical pharmacologyen
dc.subjectAdverse drug reactionsen
dc.subjectMedication errorsen
dc.subjectClinical pharmacologyen
dc.subjectPatient safetyen
dc.subjectClinical pharmacologyen
dc.titleDevelopment of a standardized chart review method to identify drug-related hospital admissions in older peopleen
dc.typeArticle (peer-reviewed)en
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