Rationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trial

Simple item page
dc.contributor.authorAdam, Luise
dc.contributor.authorMoutzouri, Elisavet
dc.contributor.authorBaumgartner, Christine
dc.contributor.authorLoewe, Axel Lennart
dc.contributor.authorFeller, Martin
dc.contributor.authorM'Rabet-Bensalah, Khadija
dc.contributor.authorSchwab, Nathalie
dc.contributor.authorHossmann, Stefanie
dc.contributor.authorSchneider, Claudio
dc.contributor.authorJegerlehner, Sabrina
dc.contributor.authorFloriani, Carmen
dc.contributor.authorLimacher, Andreas
dc.contributor.authorJungo, Katharina Tabea
dc.contributor.authorHuibers, Corlina Johanna Alida
dc.contributor.authorStreit, Sven
dc.contributor.authorSchwenkglenks, Matthias
dc.contributor.authorSpruit, Marco
dc.contributor.authorVan Dorland, Anette
dc.contributor.authorDonzé, Jacques
dc.contributor.authorKearney, Patricia M.
dc.contributor.authorJüni, Peter
dc.contributor.authorAujesky, Drahomir
dc.contributor.authorJansen, Paul
dc.contributor.authorBoland, Benoît
dc.contributor.authorDalleur, Olivia
dc.contributor.authorByrne, Stephen
dc.contributor.authorKnol, Wilma
dc.contributor.authorSpinewine, Anne
dc.contributor.authorO'Mahony, Denis
dc.contributor.authorTrelle, Sven
dc.contributor.authorRodondi, Nicolas
dc.contributor.funderSwiss State Secretariat for Education, Research and Innovation (SERI)en
dc.contributor.funderHorizon 2020en
dc.date.accessioned2019-11-20T05:47:39Z
dc.date.available2019-11-20T05:47:39Z
dc.date.issued2019-06-03
dc.description.abstractIntroduction: Multimorbidity and polypharmacy are important risk factors for drug-related hospital admissions (DRAs). DRAs are often linked to prescribing problems (overprescribing and underprescribing), as well as non-adherence with drug regimens for different reasons. In this trial, we aim to assess whether a structured medication review compared with standard care can reduce DRAs in multimorbid older patients with polypharmacy. Methods and analysis: OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people is a European multicentre, cluster randomised, controlled trial. Hospitalised patients ≥70 years with ≥3 chronic medical conditions and concurrent use of ≥5 chronic medications are included in the four participating study centres of Bern (Switzerland), Utrecht (The Netherlands), Brussels (Belgium) and Cork (Ireland). Patients treated by the same prescribing physician constitute a cluster, and clusters are randomised 1:1 to either standard care or Systematic Tool to Reduce Inappropriate Prescribing (STRIP) intervention with the help of a clinical decision support system, the STRIP Assistant. STRIP is a structured method performing customised medication reviews, based on Screening Tool of Older People’s Prescriptions/Screening  Tool to Alert to Right Treatment criteria to detect potentially inappropriate prescribing. The primary endpoint is any DRA where the main reason or a contributory reason for the patient’s admission is caused by overtreatment or undertreatment, and/or inappropriate treatment. Secondary endpoints include number of any hospitalisations, all-cause mortality, number of falls, quality of life, degree of polypharmacy, activities of daily living, patient’s drug compliance, the number of significant drug–drug interactions, drug overuse and underuse and potentially inappropriate medication.Ethics and dissemination: The local Ethics Committees in Switzerland, Ireland, The Netherlands and Belgium approved this trial protocol. We will publish the results of this trial in a peer-reviewed journal.Main funding: European Union’s Horizon 2020 programme.Trial registration number NCT02986425 , SNCTP000002183 , NTR6012, U1111-1181-9400.en
dc.description.sponsorship6342388en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleide026769en
dc.identifier.citationAdam, L., Moutzouri, E., Baumgartner, C., Loewe, A.L., Feller, M., M’Rabet-Bensalah, K., Schwab, N., Hossmann, S., Schneider, C., Jegerlehner, S. and Floriani, C., 2019. Rationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trial. BMJ open, 9(6), (e026769). DOI: 10.1136/bmjopen-2018-026769en
dc.identifier.doi10.1136/bmjopen-2018-026769en
dc.identifier.eissn2044-6055
dc.identifier.endpage9en
dc.identifier.issued6en
dc.identifier.journaltitleBMJ Openen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9136
dc.identifier.volume9en
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.relation.urihttps://bmjopen.bmj.com/content/9/6/e026769
dc.rights© Author(s) (or their employer(s)) 2019. Published by BMJen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/. No commercial re-useen
dc.subjectOPERAMen
dc.subjectOptimising therapyen
dc.subjectHospital admissionsen
dc.subjectEuropeen
dc.titleRationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trialen
dc.typeArticle (peer-reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
e026769.full.pdf
Size:
486.33 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Public Health - Journal Articles
Medicine - Journal Articles
Pharmacy - Journal Articles