The gut microbiome and pharmacology: a prescription for therapeutic targeting of the gut-brain axis

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dc.contributor.authorLeprun, Pauline M. B.
dc.contributor.authorClarke, Gerard
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.contributor.funderAir Force Office of Scientific Researchen
dc.date.accessioned2019-05-24T08:53:57Z
dc.date.available2019-05-24T08:53:57Z
dc.date.issued2019-05-10
dc.date.updated2019-05-24T08:45:04Z
dc.description.abstractNew frontiers for host-microbe interactions continue to emerge as our knowledge of the adult gut microbiome in health and disease is continually supplemented and improved. Alterations in the gut microbiota composition in irritable bowel syndrome (IBS) are now linked to symptom severity while population-based evidence linking gut microbiome signatures to depression is an important new landmark. The effects of drugs on gut microbiome composition are also becoming clearer. Meanwhile, preclinical studies have delineated the influence of the gut microbiome at a structural and activity level in distinct brain regions. Bacterial metabolites, such as tryptamine, can activate specific receptors to impact gastrointestinal motility. These recent studies bring into focus the future implications for therapeutic targeting of the microbiomeâ gutâ brain axis.en
dc.description.sponsorshipHealth Research Board (Grant number ILP-POR-2017-013); Air Force Office of Scientific Research (Grant number FA9550-17-1-006)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationLeprun, P. M. B. and Clarke, G. (2019) 'The gut microbiome and pharmacology: a prescription for therapeutic targeting of the gut-brain axis', Current Opinion in Pharmacology, 49, pp. 17-23. doi: 10.1016/j.coph.2019.04.007en
dc.identifier.doi10.1016/j.coph.2019.04.007en
dc.identifier.eissn1471-4973
dc.identifier.endpage23en
dc.identifier.issn1471-4892
dc.identifier.journaltitleCurrent Opinion in Pharmacologyen
dc.identifier.startpage17en
dc.identifier.urihttps://hdl.handle.net/10468/7974
dc.identifier.volume49en
dc.language.isoenen
dc.publisherElsevier Ltd.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S1471489218301516
dc.rights© 2019, Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC BY-NC-ND 4.0 license.en
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectGut microbiomeen
dc.subjectDepressionen
dc.subjectTryptamineen
dc.titleThe gut microbiome and pharmacology: a prescription for therapeutic targeting of the gut-brain axisen
dc.typeArticle (peer-reviewed)en
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