The gut microbiota-immune-brain axis: Therapeutic implications
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Published Version
Date
2025
Authors
O'Riordan, Kenneth J.
Moloney, Gerard M.
Keane, Lily
Clarke, Gerard
Cryan, John F.
Journal Title
Journal ISSN
Volume Title
Publisher
Cell Press
Published Version
Abstract
The microbiota-gut-brain axis has major implications for human health including gastrointestinal physiology, brain function, and behavior. The immune system represents a key pathway of communication along this axis with the microbiome implicated in neuroinflammation in health and disease. In this review, we discuss the mechanisms as to how the gut microbiota interacts with the brain, focusing on innate and adaptive immunity that are often disrupted in gut-brain axis disorders. We also consider the implications of these observations and how they can be advanced by interdisciplinary research. Leveraging an increased understanding of how these interactions regulate immunity has the potential to usher in a new era of precision neuropsychiatric clinical interventions for psychiatric, neurodevelopmental, and neurological disorders. © 2025 The Authors
Description
Keywords
Adaptive immunity , Gut microbiota , Innate immunity , Microbiome-gut-immune-brain axis
Citation
O’Riordan, K. J., Moloney, G. M., Keane, L., Clarke, G. and Cryan, J. F. (2025) 'The gut microbiota-immune-brain axis: Therapeutic implications', Cell Reports Medicine, 6(3), 101982. DOI: 10.1016/j.xcrm.2025.101982