The gut microbiota-immune-brain axis: Therapeutic implications

Simple item page
dc.contributor.authorO'Riordan, Kenneth J.en
dc.contributor.authorMoloney, Gerard M.en
dc.contributor.authorKeane, Lilyen
dc.contributor.authorClarke, Gerarden
dc.contributor.authorCryan, John F.en
dc.contributor.funderIan's Friends Foundationen
dc.contributor.funderSaks-Kavanaugh Foundationen
dc.contributor.funderDuPonten
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschungen
dc.date.accessioned2025-04-23T11:15:01Z
dc.date.available2025-04-23T11:15:01Z
dc.date.issued2025en
dc.description.abstractThe microbiota-gut-brain axis has major implications for human health including gastrointestinal physiology, brain function, and behavior. The immune system represents a key pathway of communication along this axis with the microbiome implicated in neuroinflammation in health and disease. In this review, we discuss the mechanisms as to how the gut microbiota interacts with the brain, focusing on innate and adaptive immunity that are often disrupted in gut-brain axis disorders. We also consider the implications of these observations and how they can be advanced by interdisciplinary research. Leveraging an increased understanding of how these interactions regulate immunity has the potential to usher in a new era of precision neuropsychiatric clinical interventions for psychiatric, neurodevelopmental, and neurological disorders. © 2025 The Authorsen
dc.description.sponsorshipScience Foundation Ireland (SFI/12/RC/2273_P2); Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CRSII5_186346/NMS2068)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid101982en
dc.identifier.citationO’Riordan, K. J., Moloney, G. M., Keane, L., Clarke, G. and Cryan, J. F. (2025) 'The gut microbiota-immune-brain axis: Therapeutic implications', Cell Reports Medicine, 6(3), 101982. DOI: 10.1016/j.xcrm.2025.101982en
dc.identifier.doi10.1016/j.xcrm.2025.101982en
dc.identifier.issn26663791en
dc.identifier.issued3
dc.identifier.journaltitleCell Reports Medicineen
dc.identifier.urihttps://hdl.handle.net/10468/17304
dc.identifier.volume6
dc.language.isoenen
dc.publisherCell Pressen
dc.relation.projectSFI/12/RC/2273_P2en
dc.rights© 2025, the Author(s). Open Accessen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAdaptive immunityen
dc.subjectGut microbiotaen
dc.subjectInnate immunityen
dc.subjectMicrobiome-gut-immune-brain axisen
dc.titleThe gut microbiota-immune-brain axis: Therapeutic implicationsen
dc.typeArticle (peer reviewed)en
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S2666379125000552-main.pdf
Size:
4.41 MB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
Collections
APC Microbiome Ireland - Journal Articles
Anatomy and Neuroscience - Journal Articles
Psychiatry - Journal Articles