Celiac plexus radiosurgery for retroperitoneal pain in advanced cancer: a pre-specified secondary analysis of health-related quality of life in a phase II single-arm trial

Simple item page
dc.contributor.authorBarry, A.S.
dc.contributor.authorFluss, R.
dc.contributor.authorDawson, L.A.
dc.contributor.authorHausner, D.
dc.contributor.authorBuckstein, M.
dc.contributor.authorGolin, T.
dc.contributor.authorFreedman, L.
dc.contributor.authorMiszczyk, M.
dc.contributor.authorDiazPardo, D.
dc.contributor.authorAguiar, A.
dc.contributor.authorLimon, D.
dc.contributor.authorPfeffer, R.M.
dc.contributor.authorBen-Ayun, M.
dc.contributor.authorHammer, L.
dc.contributor.authorSymon, Z.
dc.contributor.authorMorag, O.
dc.contributor.authorJacobson, G.
dc.contributor.authorDicker, A.
dc.contributor.authorWydmanski, J.
dc.contributor.authorZimmermann, C.
dc.contributor.authorLawrence, Y.R.
dc.contributor.funderUniversity of Texas MD Anderson Cancer Center
dc.contributor.funderIsraeli Center for Cardiovascular Research
dc.contributor.funderBader Philanthropies, BPI, SHEBA-17-4292-YL-CTIL-NCTO3323489
dc.date.accessioned2026-05-14T14:50:16Z
dc.date.available2026-05-14T14:50:16Z
dc.date.issued2026-05-13
dc.description.abstractBackground: Retroperitoneal pain syndrome seen in pancreatic cancer is a major clinical challenge. Celiac plexus radiosurgery, a new palliative technique for retroperitoneal pain syndrome, decreased pain levels in a phase II study. Here Health-Related Quality of Life (HRQOL) outcomes are reported. Methods: Evaluable patients, who were enrolled between January 2018 and December 2021, in an international single-arm Phase II ethics-approved study (NCT03323489), were included. The pre-specified secondary endpoint–change in HRQOL from baseline to 3- and 6-weeks post-treatment, was measured by the Functional Assessment of Cancer Therapy – Hepatobiliary (FACT-Hep) version 4 questionnaire. Mean change was deemed clinically significant (CS) if the lower bound of the 95% confidence interval was above the predefined minimal clinically important difference (MCID) for that outcome. Findings: Of 90 evaluable patients, 51 (57%) and 44 (49%) had HRQOL FACT-Hep scores available at 3- and 6-weeks, compared to baseline. The majority of patients had pancreatic cancer (90%) and mean daily intravenous morphine equivalent consumption was 35.9 mg (SD 67.6).The mean increase of FACT-Hep total score from baseline was 9.3 points at 3-weeks (p = 0.0017) and 19.6 points at 6-weeks (p < 0.0001, 95% CI 13–26.3), representing a statistically significant (SS) 22% improvement from baseline, with CS demonstrated at 6-weeks. A sensitivity analysis, imputing no change from baseline in patients with missing data, demonstrated similar results. On multivariable analysis, lower baseline opioid use and baseline FACT-Hep scores were associated with an increased change in FACT-Hep from baseline to 3-weeks. Interpretation: Celiac plexus radiosurgery was associated with a SS improvement in HRQOL amongst patients with retroperitoneal pain at 3-weeks, and a SS and CS improvement at 6-weeks post intervention. Funding: This study received major financial support provided by Gateway for Cancer Research (G-17-100), additional support was provided from the Israel Cancer Association (20170128 and 20181272).en
dc.description.sponsorshipWe thank our research coordinators, and those who contributed to accrual and patient care, in particular Dr. Malgorzata Malec-Milewska. We thankFACIT.orgfor use of the Functional Assessment of Chronic Illness Therapy system of Quality of Life questionnaires and all related subscales, translations, and adaptations (“FACIT System”). We thank The University of Texas MD Anderson Cancer Center for use of the Brief Pain Inventory short form (BPI-SF
dc.description.sponsorshiplicense SHEBA-17-4292-YL-CTIL-NCTO3323489). We thank The Israeli Center for Cardiovascular Research for providing research management.
dc.description.versionPublished Version
dc.format.extent10
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid103968
dc.identifier.authororcidBarry, A.S.§0000-0003-2734-7090
dc.identifier.authororcidFluss, R.
dc.identifier.authororcidDawson, L.A.
dc.identifier.authororcidHausner, D.
dc.identifier.authororcidBuckstein, M.
dc.identifier.authororcidGolin, T.
dc.identifier.authororcidFreedman, L.
dc.identifier.authororcidMiszczyk, M.
dc.identifier.authororcidDiazPardo, D.
dc.identifier.authororcidAguiar, A.
dc.identifier.authororcidLimon, D.
dc.identifier.authororcidPfeffer, R.M.
dc.identifier.authororcidBen-Ayun, M.
dc.identifier.authororcidHammer, L.
dc.identifier.authororcidSymon, Z.
dc.identifier.authororcidMorag, O.
dc.identifier.authororcidJacobson, G.
dc.identifier.authororcidDicker, A.
dc.identifier.authororcidWydmanski, J.
dc.identifier.authororcidZimmermann, C.
dc.identifier.authororcidLawrence, Y.R.
dc.identifier.citationBarry, A S, Fluss, R, Dawson, L A, Hausner, D, Buckstein, M, Golin, T, Freedman, L, Miszczyk, M, DiazPardo, D, Aguiar, A, Limon, D, Pfeffer, R M, Ben-Ayun, M, Hammer, L, Symon, Z, Morag, O, Jacobson, G, Dicker, A, Wydmanski, J, Zimmermann, C & Lawrence, Y R 2026, 'Celiac plexus radiosurgery for retroperitoneal pain in advanced cancer: a pre-specified secondary analysis of health-related quality of life in a phase II single-arm trial', eClinicalMedicine, vol. 95, 103968. < https://www.scopus.com/pages/publications/105037899797?origin=resultslist >
dc.identifier.issn2589-5370
dc.identifier.journaltitleeClinicalMedicine
dc.identifier.otherRIS: urn:D9F25A939458D28480925868D7C6A193
dc.identifier.otherORCID: /0000-0003-2734-7090/work/214723593
dc.identifier.urihttps://hdl.handle.net/10468/18765
dc.identifier.volume95
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.urihttps://www.scopus.com/pages/publications/105037899797
dc.relation.urihttps://www.scopus.com/pages/publications/105037899797?origin=resultslist
dc.rightsPublisher Copyright: © 2026 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0/
dc.rights.accessrightsopen access
dc.rights.licensenameAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.statusPeer reviewed
dc.subjectCeliac plexus
dc.subjectPain
dc.subjectPancreas cancer
dc.subjectRadiotherapy
dc.subjectSBRT
dc.subjectSRS
dc.subject[Medicine]
dc.titleCeliac plexus radiosurgery for retroperitoneal pain in advanced cancer: a pre-specified secondary analysis of health-related quality of life in a phase II single-arm trialen
dc.typeArticle (peer-reviewed)
Files
Original bundle
Now showing 1 - 5 of 5
Thumbnail Image
Name:
mmc3_2_.docx
Size:
40.8 KB
Format:
Microsoft Word XML
Download
Thumbnail Image
Name:
mmc1_3_.docx
Size:
52.59 KB
Format:
Microsoft Word XML
Download
Thumbnail Image
Name:
mmc4_1_.pdf
Size:
555.84 KB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
mmc2_1_.docx
Size:
22.15 KB
Format:
Microsoft Word XML
Download
Thumbnail Image
Name:
PIIS2589537026002166.pdf
Size:
967.78 KB
Format:
Adobe Portable Document Format
Description:
Published Version
Download
Collections
School of Medicine