Neurobiological effects of phospholipids in vitro: relevance to stress-related disorders

dc.contributor.authorDonoso, Francisco
dc.contributor.authorSchverer, Marina
dc.contributor.authorRea, Kieran
dc.contributor.authorPusceddu, Matteo M.
dc.contributor.authorRoy, Bernard L.
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorCryan, John F.
dc.contributor.authorSchellekens, Harriët
dc.contributor.funderScience Foundation Irelanden
dc.date.accessioned2022-03-16T17:16:46Z
dc.date.available2022-03-16T17:16:46Z
dc.date.issued2020-11
dc.date.updated2022-03-16T16:49:55Z
dc.description.abstractNutrition is a crucial component for maintenance of brain function and mental health. Accumulating evidence suggests that certain molecular compounds derived from diet can exert neuroprotective effects against chronic stress, and moreover improve important neuronal processes vulnerable to the stress response, such as plasticity and neurogenesis. Phospholipids are naturally occurring amphipathic molecules with promising potential to promote brain health. However, it is unclear whether phospholipids are able to modulate neuronal function directly under a stress-related context. In this study, we investigate the neuroprotective effects of phosphatidylcholine (PC), lysophosphatidylcholine (LPC), phosphatidylserine (PS), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylglycerol (PG), phosphatidic acid (PA), sphingomyelin (SM) and cardiolipin (CL) against corticosterone (CORT)-induced cytotoxicity in primary cultured rat cortical neurons. In addition, we examine their capacity to modulate proliferation and differentiation of hippocampal neural progenitor cells (NPCs).We show that PS, PG and PE can reverse CORT-induced cytotoxicity and neuronal depletion in cortical cells. On the other hand, phospholipid exposure was unable to prevent the decrease of Bdnf expression produced by CORT. Interestingly, PS was able to increase hippocampal NPCs neurosphere size, and PE elicited a significant increase in astrocytic differentiation in hippocampal NPCs. Together, these results indicate that specific phospholipids protect cortical cells against CORT-induced cytotoxicity and improve proliferation and astrocytic differentiation in hippocampal NPCs, suggesting potential implications on neurodevelopmental and neuroprotective pathways relevant for stress-related disorders.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid100252en
dc.identifier.citationDonoso, F., Schverer, M., Rea, K., Pusceddu, M. M., Roy, B. L., Dinan, T. G., Cryan, J. F. and Schellekens, H. (2020) 'Neurobiological effects of phospholipids in vitro: relevance to stress-related disorders', Neurobiology of Stress, 13, 100252 (12 pp). doi: 10.1016/j.ynstr.2020.100252en
dc.identifier.doi10.1016/j.ynstr.2020.100252en
dc.identifier.endpage12en
dc.identifier.issn2352-2895
dc.identifier.journaltitleNeurobiology of Stressen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/12940
dc.identifier.volume13en
dc.language.isoenen
dc.publisherElsevier B.V.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.rights© 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAdult hippocampal neurogenesisen
dc.subjectMajor depressionen
dc.subjectDietary phospholipidsen
dc.subjectMolecular-mechanismsen
dc.subjectNeurotrophic factoren
dc.subjectNeuronal damageen
dc.subjectHPA axisen
dc.subjectCorticosteroneen
dc.subjectBrainen
dc.subjectBDNFen
dc.titleNeurobiological effects of phospholipids in vitro: relevance to stress-related disordersen
dc.typeArticle (peer-reviewed)en
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