dc.contributor.author	McCarthy, Fergus P.
dc.contributor.author	Gill, Carolyn
dc.contributor.author	Seed, Paul, T.
dc.contributor.author	Bramham, K.
dc.contributor.author	Chappell, Lucy C.
dc.contributor.author	Shennan, Andrew, H.
dc.contributor.funder	NIHR Clinical Academic Fellowship	en
dc.contributor.funder	Tommy’s Charity UK	en
dc.contributor.funder	NIHR Biomedical ResearchCentre at Guy’s and St Thomas’ NHS Foundation Trust	en
dc.contributor.funder	King’s College London	en
dc.contributor.funder	European Commission	en
dc.date.accessioned	2019-04-29T13:48:56Z
dc.date.available	2019-04-29T13:48:56Z
dc.date.issued	2019-01
dc.description.abstract	To compare the performance of three placental growth factor (PlGF)-based tests in predicting delivery within 14 days from testing in women with suspected preterm pre-eclampsia before 35 weeks' gestation. Methods: This was a retrospective analysis of samples collected from three prospective pregnancy cohort studies. Participants were pregnant women with suspected preterm pre-eclampsia recruited in tertiary maternity units in the UK and Ireland. Samples were analyzed simultaneously according to the manufacturers' directions. The tests compared were the DELFIA Xpress PlGF 1-2-3 test, the Triage PlGF test and the Elecsys immunoassay soluble fms-like tyrosine kinase-1 (sFlt-1)/PlGF ratio. Areas under receiver–operating characteristics curves (AUCs) were compared. The main outcome measure was detection of a difference of 0.05 in AUC between tests for delivery within 14 days of testing. Results Plasma samples from 396 women and serum samples from 244 women were assayed. In predicting delivery within 14 days secondary to suspected pre-eclampsia prior to 35 weeks' gestation, no significant differences were observed in AUCs (P = 0.795), sensitivities (P = 0.249), positive predictive values (P = 0.765) or negative predictive values (P = 0.920) between the three tests. The specificity of the Elecsys sFlt-1/PlGF ratio test was higher than that of the other two tests (P < 0.001). Conclusions: The tests perform similarly in their prediction of need for delivery within 14 days in women with suspected pre-eclampsia. The high negative predictive values support the role of PlGF-based tests as ‘rule-out’ tests for pre-eclampsia.	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	McCarthy, F.P., Gill, C., Seed, P.T., Bramham, K., Chappell, L.C. and Shennan, A.H., 2019. Comparison of three commercially available placental growth factor‐based tests in women with suspected preterm pre‐eclampsia: the COMPARE study. Ultrasound in Obstetrics & Gynecology, 53(1), (6pp.) DOI: 10.1002/uog.19051	en
dc.identifier.doi	10.1002/uog.19051	en
dc.identifier.endpage	67	en
dc.identifier.issn	0960-7692
dc.identifier.issued	1	en
dc.identifier.journaltitle	Ultrasound in Obstetrics & Gynecology	en
dc.identifier.startpage	62	en
dc.identifier.uri	https://hdl.handle.net/10468/7817
dc.identifier.volume	53	en
dc.language.iso	en	en
dc.publisher	Wiley	en
dc.relation.project	Perkin Elmer	en
dc.relation.uri	https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/uog.19051
dc.rights	© 2018 The Author(s)	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	en
dc.subject	DELFIA Xpress PlGF 1-2-3 test (Perkin Elmer)	en
dc.subject	Elecsys immunoassay sFlt-1/PlGF ratio (Roche)	en
dc.subject	Triage PlGF (Alere)	en
dc.subject	Placental growth factor	en
dc.subject	Pre-eclampsia	en
dc.subject	Soluble Flt-1	en
dc.title	Comparison of three commercially available placental growth factor-based tests in women with suspected preterm pre-eclampsia: the COMPARE study	en
dc.type	Article (peer-reviewed)	en

Comparison of three commercially available placental growth factor-based tests in women with suspected preterm pre-eclampsia: the COMPARE study

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