Comparison of three commercially available placental growth factor-based tests in women with suspected preterm pre-eclampsia: the COMPARE study

dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.authorGill, Carolyn
dc.contributor.authorSeed, Paul, T.
dc.contributor.authorBramham, K.
dc.contributor.authorChappell, Lucy C.
dc.contributor.authorShennan, Andrew, H.
dc.contributor.funderNIHR Clinical Academic Fellowshipen
dc.contributor.funderTommy’s Charity UKen
dc.contributor.funderNIHR Biomedical ResearchCentre at Guy’s and St Thomas’ NHS Foundation Trusten
dc.contributor.funderKing’s College Londonen
dc.contributor.funderEuropean Commissionen
dc.date.accessioned2019-04-29T13:48:56Z
dc.date.available2019-04-29T13:48:56Z
dc.date.issued2019-01
dc.description.abstractTo compare the performance of three placental growth factor (PlGF)-based tests in predicting delivery within 14 days from testing in women with suspected preterm pre-eclampsia before 35 weeks' gestation. Methods: This was a retrospective analysis of samples collected from three prospective pregnancy cohort studies. Participants were pregnant women with suspected preterm pre-eclampsia recruited in tertiary maternity units in the UK and Ireland. Samples were analyzed simultaneously according to the manufacturers' directions. The tests compared were the DELFIA Xpress PlGF 1-2-3 test, the Triage PlGF test and the Elecsys immunoassay soluble fms-like tyrosine kinase-1 (sFlt-1)/PlGF ratio. Areas under receiver–operating characteristics curves (AUCs) were compared. The main outcome measure was detection of a difference of 0.05 in AUC between tests for delivery within 14 days of testing. Results Plasma samples from 396 women and serum samples from 244 women were assayed. In predicting delivery within 14 days secondary to suspected pre-eclampsia prior to 35 weeks' gestation, no significant differences were observed in AUCs (P = 0.795), sensitivities (P = 0.249), positive predictive values (P = 0.765) or negative predictive values (P = 0.920) between the three tests. The specificity of the Elecsys sFlt-1/PlGF ratio test was higher than that of the other two tests (P < 0.001). Conclusions: The tests perform similarly in their prediction of need for delivery within 14 days in women with suspected pre-eclampsia. The high negative predictive values support the role of PlGF-based tests as ‘rule-out’ tests for pre-eclampsia.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMcCarthy, F.P., Gill, C., Seed, P.T., Bramham, K., Chappell, L.C. and Shennan, A.H., 2019. Comparison of three commercially available placental growth factor‐based tests in women with suspected preterm pre‐eclampsia: the COMPARE study. Ultrasound in Obstetrics & Gynecology, 53(1), (6pp.) DOI: 10.1002/uog.19051en
dc.identifier.doi10.1002/uog.19051en
dc.identifier.endpage67en
dc.identifier.issn0960-7692
dc.identifier.issued1en
dc.identifier.journaltitleUltrasound in Obstetrics & Gynecologyen
dc.identifier.startpage62en
dc.identifier.urihttps://hdl.handle.net/10468/7817
dc.identifier.volume53en
dc.language.isoenen
dc.publisherWileyen
dc.relation.projectPerkin Elmeren
dc.relation.urihttps://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/uog.19051
dc.rights© 2018 The Author(s)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectDELFIA Xpress PlGF 1-2-3 test (Perkin Elmer)en
dc.subjectElecsys immunoassay sFlt-1/PlGF ratio (Roche)en
dc.subjectTriage PlGF (Alere)en
dc.subjectPlacental growth factoren
dc.subjectPre-eclampsiaen
dc.subjectSoluble Flt-1en
dc.titleComparison of three commercially available placental growth factor-based tests in women with suspected preterm pre-eclampsia: the COMPARE studyen
dc.typeArticle (peer-reviewed)en
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