Gut microbiota composition correlates with diet and health in the elderly

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dc.contributor.author Claesson, Marcus J.
dc.contributor.author Jeffery, Ian B.
dc.contributor.author Conde, Susana
dc.contributor.author Power, Susan E.
dc.contributor.author O'Connor, Eibhlí­s M.
dc.contributor.author Cusack, Siobhán
dc.contributor.author Harris, Hugh M. B.
dc.contributor.author Coakley, Mairead
dc.contributor.author Lakshminarayanan, Bhuvaneswari
dc.contributor.author O'Sullivan, Orla
dc.contributor.author Fitzgerald, Gerald F.
dc.contributor.author Deane, Jennifer
dc.contributor.author O'Connor, Michael
dc.contributor.author Harnedy, Norma
dc.contributor.author O'Connor, Kieran
dc.contributor.author O'Mahony, Denis
dc.contributor.author van Sinderen, Douwe
dc.contributor.author Wallace, Martina
dc.contributor.author Brennan, Lorraine
dc.contributor.author Stanton, Catherine
dc.contributor.author Marchesi, Julian R.
dc.contributor.author Fitzgerald, Anthony P.
dc.contributor.author Shanahan, Fergus
dc.contributor.author Hill, Colin
dc.contributor.author Ross, R. Paul
dc.contributor.author O'Toole, Paul W.
dc.date.accessioned 2020-10-13T11:51:10Z
dc.date.available 2020-10-13T11:51:10Z
dc.date.issued 2012-07-13
dc.identifier.citation Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., Fitzgerald, G. F., Deane, J., O’Connor, M., Harnedy, N., O’Connor, K., O’Mahony, D., van Sinderen, D., Wallace, M., Brennan, L., Stanton, C., Marchesi, J. R., Fitzgerald, A. P., Shanahan, F., Hill, C., Ross, R. P. and O’Toole, P. W. (2012) ‘Gut microbiota composition correlates with diet and health in the elderly’, Nature, 488, pp. 178–184. doi: 10.1038/nature11319 en
dc.identifier.volume 488 en
dc.identifier.startpage 178 en
dc.identifier.endpage 184 en
dc.identifier.issn 0028-0836
dc.identifier.uri http://hdl.handle.net/10468/10653
dc.identifier.doi 10.1038/nature11319 en
dc.description.abstract Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with increased frailty. Collectively, the data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing. en
dc.description.sponsorship Department of Agriculture Food and Marine and Health Research Board (FHRI award to the ELDERMET project); Science Foundation Ireland (Award to the Alimentary Pharmabiotic Centre, University College Cork); Health Research Board (Fellowship) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Macmillan Publishers Limited en
dc.rights © 2012, Macmillan Publishers Limited. All rights reserved. This is a post-peer-review, pre-copyedit version of an article published in Nature. The final authenticated version is available online at: https://doi.org/10.1038/nature11319 en
dc.subject Fecal microbiota en
dc.subject Phylogenetic microarray en
dc.subject Sequences en
dc.subject Regression en
dc.subject Intestine en
dc.subject Taxonomy en
dc.subject Disease en
dc.subject Index en
dc.subject Age en
dc.title Gut microbiota composition correlates with diet and health in the elderly en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Paul O'Toole, Microbiology, University College Cork, Cork, Ireland. +353-21-490-3000 Email: pwotoole@ucc.ie en
dc.internal.availability Full text available en
dc.date.updated 2020-10-13T11:33:40Z
dc.description.version Accepted Version en
dc.internal.rssid 389908631
dc.internal.wokid WOS:000307267000026
dc.contributor.funder Department of Agriculture, Food and the Marine, Ireland en
dc.contributor.funder Health Research Board en
dc.contributor.funder Science Foundation Ireland en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Nature en
dc.internal.copyrightchecked Yes
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress pwotoole@ucc.ie en
dc.identifier.eissn 1476-4687


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