Development of a standardized chart review method to identify drug-related hospital admissions in older people

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dc.contributor.author Thevelin, Stefanie
dc.contributor.author Spinewine, Anne
dc.contributor.author Beuscart, Jean-Baptiste
dc.contributor.author Boland, Benoit
dc.contributor.author Marien, Sophie
dc.contributor.author Vaillant, Fanny
dc.contributor.author Wilting, Ingeborg
dc.contributor.author Vondeling, Ariel
dc.contributor.author Floriani, Carmen
dc.contributor.author Schneider, Claudio
dc.contributor.author Donzé, Jacques
dc.contributor.author Rodondi, Nicolas
dc.contributor.author Cullinan, Shane
dc.contributor.author O'Mahony, Denis
dc.contributor.author Dalleur, Olivia
dc.date.accessioned 2018-09-24T08:10:51Z
dc.date.available 2018-09-24T08:10:51Z
dc.date.issued 2018-07-14
dc.identifier.citation Thevelin, S., Spinewine, A., Beuscart, J.-B., Boland, B., Marien, S., Vaillant, F., Wilting, I., Vondeling, A., Floriani, C., Schneider, C.,Donzé J., Rodondi, N., Cullinan, S., O'Mahony, D. and Dalleur, O. (2018) 'Development of a standardized chart review method to identify drug-related hospital admissions in older people', British Journal of Clinical Pharmacology. doi: 10.1111/bcp.13716 en
dc.identifier.issn 0306-5251
dc.identifier.issn 1365-2125
dc.identifier.uri http://hdl.handle.net/10468/6866
dc.identifier.doi 10.1111/bcp.13716
dc.description.abstract Aim: We aimed to develop a standardized chart review method to identify drug-related hospital admissions (DRA) in older people caused by non-preventable adverse drug reactions and preventable medication errors including overuse, underuse and misuse of medications: the DRA adjudication guide. Methods: The DRA adjudication guide was developed based on design and test iterations with international and multidisciplinary input in 4 subsequent steps: literature review, evaluation of content validity using a Delphi consensus technique, a pilot test and a reliability study. Results: The DRA adjudication guide provides definitions, examples and step-by-step instructions to measure DRA. A 3-step standardized chart review method was elaborated including 1) data abstraction, 2) explicit screening with a newly developed trigger tool for DRA in older people and 3) consensus adjudication for causality by a pharmacist and a physician using the World Health Organization-Uppsala Monitoring Centre and Hallas criteria. A 15-member international Delphi panel reached consensus agreement on 26 triggers for DRA in older people. The DRA adjudication guide showed good feasibility of use and achieved moderate inter-rater reliability for the evaluation of 16 cases by 4 European adjudication pairs (71% agreement, kappa = 0.41). Disagreements arose mainly for cases with potential underuse. Conclusions: The DRA adjudication guide is the first standardized chart review method to identify DRA in older persons. Content validity, feasibility of use and inter-rater reliability were found to be satisfactory. The method can be used as an outcome measure for interventions targeted at improving quality and safety of medication use in older people. en
dc.description.sponsorship State Secretariat for Education, Research and Innovation, Switzerland (Contract Number 15.0137) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher John Wiley & Sons, Inc. on behalf of the British Pharmacological Society en
dc.rights © 2018, the British Pharmacological Society. Published by John Wiley & Sons, Inc. This is the peer reviewed version of the following article: Thevelin, S., Spinewine, A., Beuscart, J.-B., Boland, B., Marien, S., Vaillant, F., Wilting, I., Vondeling, A., Floriani, C., Schneider, C.,Donzé J., Rodondi, N., Cullinan, S., O'Mahony, D. and Dalleur, O. (2018) 'Development of a standardized chart review method to identify drug-related hospital admissions in older people', British Journal of Clinical Pharmacology. doi: 10.1111/bcp.13716, which has been published in final form at https://doi.org/10.1111/bcp.13716. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. en
dc.subject Elderly en
dc.subject Geriatrics en
dc.subject Medication safety en
dc.subject Clinical pharmacology en
dc.subject Adverse drug reactions en
dc.subject Medication errors en
dc.subject Clinical pharmacology en
dc.subject Patient safety en
dc.subject Clinical pharmacology en
dc.title Development of a standardized chart review method to identify drug-related hospital admissions in older people en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Denis O'Mahony, Medicine Department, University College Cork, Cork, Ireland. +353-21-490-3000 Email: denis.omahony@ucc.ie en
dc.internal.availability Full text available en
dc.check.info Access to this article is restricted until 12 months after publication by request of the publisher. en
dc.check.date 2019-07-14
dc.date.updated 2018-09-21T11:44:24Z
dc.description.version Accepted Version en
dc.internal.rssid 454581774
dc.contributor.funder Horizon 2020 en
dc.contributor.funder State Secretariat for Education, Research and Innovation, Switzerland
dc.description.status Peer reviewed en
dc.identifier.journaltitle British Journal of Clinical Pharmacology en
dc.internal.copyrightchecked Yes en
dc.internal.licenseacceptance Yes en
dc.internal.IRISemailaddress denis.omahony@ucc.ie en
dc.internal.bibliocheck In press. Check for vol. / issue / page numbers. Amend citation as necessary.
dc.relation.project info:eu-repo/grantAgreement/EC/H2020::RIA/634238/EU/OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly/OPERAM en


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