Comparison of three commercially available placental growth factor-based tests in women with suspected preterm pre-eclampsia: the COMPARE study

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dc.contributor.author McCarthy, Fergus P.
dc.contributor.author Gill, Carolyn
dc.contributor.author Seed, Paul, T.
dc.contributor.author Bramham, K.
dc.contributor.author Chappell, Lucy C.
dc.contributor.author Shennan, Andrew, H.
dc.date.accessioned 2019-04-29T13:48:56Z
dc.date.available 2019-04-29T13:48:56Z
dc.date.issued 2019-01
dc.identifier.citation McCarthy, F.P., Gill, C., Seed, P.T., Bramham, K., Chappell, L.C. and Shennan, A.H., 2019. Comparison of three commercially available placental growth factor‐based tests in women with suspected preterm pre‐eclampsia: the COMPARE study. Ultrasound in Obstetrics & Gynecology, 53(1), (6pp.) DOI: 10.1002/uog.19051 en
dc.identifier.volume 53 en
dc.identifier.issued 1 en
dc.identifier.startpage 62 en
dc.identifier.endpage 67 en
dc.identifier.issn 0960-7692
dc.identifier.uri http://hdl.handle.net/10468/7817
dc.identifier.doi 10.1002/uog.19051 en
dc.description.abstract To compare the performance of three placental growth factor (PlGF)-based tests in predicting delivery within 14 days from testing in women with suspected preterm pre-eclampsia before 35 weeks' gestation. Methods: This was a retrospective analysis of samples collected from three prospective pregnancy cohort studies. Participants were pregnant women with suspected preterm pre-eclampsia recruited in tertiary maternity units in the UK and Ireland. Samples were analyzed simultaneously according to the manufacturers' directions. The tests compared were the DELFIA Xpress PlGF 1-2-3 test, the Triage PlGF test and the Elecsys immunoassay soluble fms-like tyrosine kinase-1 (sFlt-1)/PlGF ratio. Areas under receiver–operating characteristics curves (AUCs) were compared. The main outcome measure was detection of a difference of 0.05 in AUC between tests for delivery within 14 days of testing. Results Plasma samples from 396 women and serum samples from 244 women were assayed. In predicting delivery within 14 days secondary to suspected pre-eclampsia prior to 35 weeks' gestation, no significant differences were observed in AUCs (P = 0.795), sensitivities (P = 0.249), positive predictive values (P = 0.765) or negative predictive values (P = 0.920) between the three tests. The specificity of the Elecsys sFlt-1/PlGF ratio test was higher than that of the other two tests (P < 0.001). Conclusions: The tests perform similarly in their prediction of need for delivery within 14 days in women with suspected pre-eclampsia. The high negative predictive values support the role of PlGF-based tests as ‘rule-out’ tests for pre-eclampsia. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.relation.uri https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/uog.19051
dc.rights © 2018 The Author(s) en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject DELFIA Xpress PlGF 1-2-3 test (Perkin Elmer) en
dc.subject Elecsys immunoassay sFlt-1/PlGF ratio (Roche) en
dc.subject Triage PlGF (Alere) en
dc.subject Placental growth factor en
dc.subject Pre-eclampsia en
dc.subject Soluble Flt-1 en
dc.title Comparison of three commercially available placental growth factor-based tests in women with suspected preterm pre-eclampsia: the COMPARE study en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Dr Fergus P. McCarthy, The Irish Centre for Fetal and Neonatal Translational Research, University College Cork, Cork, Ireland. +353-21-490-3000 Email: fergus.mccarthy@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder NIHR Clinical Academic Fellowship en
dc.contributor.funder Tommy’s Charity UK en
dc.contributor.funder NIHR Biomedical ResearchCentre at Guy’s and St Thomas’ NHS Foundation Trust en
dc.contributor.funder King’s College London en
dc.contributor.funder European Commission en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Ultrasound in Obstetrics & Gynecology en
dc.internal.IRISemailaddress fergus.mccarthy@ucc.ie en
dc.relation.project Perkin Elmer en


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