The gut microbiome and pharmacology: a prescription for therapeutic targeting of the gut-brain axis
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Accepted Version
Date
2019-05-10
Authors
Leprun, Pauline M. B.
Clarke, Gerard
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Ltd.
Published Version
Abstract
New frontiers for host-microbe interactions continue to emerge as our knowledge of the adult gut microbiome in health and disease is continually supplemented and improved. Alterations in the gut microbiota composition in irritable bowel syndrome (IBS) are now linked to symptom severity while population-based evidence linking gut microbiome signatures to depression is an important new landmark. The effects of drugs on gut microbiome composition are also becoming clearer. Meanwhile, preclinical studies have delineated the influence of the gut microbiome at a structural and activity level in distinct brain regions. Bacterial metabolites, such as tryptamine, can activate specific receptors to impact gastrointestinal motility. These recent studies bring into focus the future implications for therapeutic targeting of the microbiomeâ gutâ brain axis.
Description
Keywords
Gut microbiome , Depression , Tryptamine
Citation
Leprun, P. M. B. and Clarke, G. (2019) 'The gut microbiome and pharmacology: a prescription for therapeutic targeting of the gut-brain axis', Current Opinion in Pharmacology, 49, pp. 17-23. doi: 10.1016/j.coph.2019.04.007