EAACI position paper: influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis
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Date
2019-04-29
Authors
Venter, Carina
Meyer, Rosan W.
Nwaru, Bright I.
Roduit, Caroline
Untersmayr, Eva
Adel-Patient, Karine
Agache, Ioana
Agostoni, Carlo
Akdis, Cezmi A.
Bischoff, Stephan
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley & Sons, Inc.
Published Version
Abstract
The prevalence of allergic diseases such as allergic rhinitis, asthma, food allergy, and atopic dermatitis has increased dramatically during the last decades, which is associated with altered environmental exposures and lifestyle practices. The purpose of this review was to highlight the potential role for dietary fatty acids, in the prevention and management of these disorders. In addition to their nutritive value, fatty acids have important immunoregulatory effects. Fatty acid-associated biological mechanisms, human epidemiology, and intervention studies are summarized in this review. The influence of genetics and the microbiome on fatty acid metabolism is also discussed. Despite critical gaps in our current knowledge, it is increasingly apparent that dietary intake of fatty acids may influence the development of inflammatory and tolerogenic immune responses. However, the lack of standardized formats (ie, food versus supplement) and standardized doses, and frequently a lack of prestudy serum fatty acid level assessments in clinical studies significantly limit our ability to compare allergy outcomes across studies and to provide clear recommendations at this time. Future studies must address these limitations and individualized medical approaches should consider the inclusion of specific dietary factors for the prevention and management of asthma, food allergy, and atopic dermatitis.
Description
Keywords
Asthma , Atopic dermatitis , Food allergy , Nutrition , Rhinitis
Citation
Venter, C., Meyer, R.W., Nwaru, B.I., Roduit, C., Untersmayr, E., Adel‐Patient, K., Agache, I., Agostoni, C., Akdis, C.A., Bischoff, S. and du Toit, G., Feeney, M., Frei, R., Garn, H., Greenhawt, M., Hoffmann‐Sommergruber, K., Lunjani, N., Maslin, K., Mills, C., Muraro, A., Pali, I., Poulson, L., Reese, I., Renz, H., Roberts, G. C., Smith, P., Smolinska, S., Sokolowska, M., Stanton, C., Vlieg‐Boerstra, B. and O'Mahony, L. (2019) ‘EAACI Position Paper: influence of dietary fatty acids on asthma, food allergy and atopic dermatitis, Allergy. doi: 10.1111/all.13764
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Copyright
© 2019, John Wiley & Sons Inc. This is the peer reviewed version of the following article: Venter, C., et al. (2019) ‘EAACI Position Paper: influence of dietary fatty acids on asthma, food allergy and atopic dermatitis, Allergy. doi: 10.1111/all.13764, which has been published in final form at https://doi.org/10.1111/all.13764. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.