AllergoOncology: microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

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dc.contributor.author Untersmayr, Eva
dc.contributor.author Bax, Heather J.
dc.contributor.author Bergmann, Christoph
dc.contributor.author Bianchini, Rodolfo
dc.contributor.author Cozen, Wendy
dc.contributor.author Gould, Hannah J.
dc.contributor.author Hartmann, Karin
dc.contributor.author Josephs, Debra H.
dc.contributor.author Levi-Schaffer, Francesca
dc.contributor.author Penichet, Manuel L.
dc.contributor.author O'Mahony, Liam
dc.contributor.author Poli, Aurelie
dc.contributor.author Redegeld, Frank A.
dc.contributor.author Roth-Walter, Franziska
dc.contributor.author Turner, Michelle C.
dc.contributor.author Vangelista, Luca
dc.contributor.author Karagiannis, Sophia N.
dc.contributor.author Jensen-Jarolim, Erika
dc.date.accessioned 2019-10-06T21:30:53Z
dc.date.available 2019-10-06T21:30:53Z
dc.date.issued 2019-06-07
dc.identifier.citation Untersmayr, E., Bax, H. J., Bergmann, C., Bianchini, R., Cozen, W., Gould, H. J., Hartmann, K., Josephs, D. H., Levi-Schaffer, F., Penichet, M. L., O'Mahony, L., Poli, A., Redegeld, F. A., Roth-Walter, F., Turner, M. C., Vangelista, L., Karagiannis, S. N. and Jensen-Jarolim, E. (2019) 'AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper', Allergy, 74(6), pp.1037-1051. DOI: 10.1111/all.13718 en
dc.identifier.volume 74 en
dc.identifier.issued 6 en
dc.identifier.startpage 1037 en
dc.identifier.endpage 1051 en
dc.identifier.issn 0105-4538
dc.identifier.uri http://hdl.handle.net/10468/8710
dc.identifier.doi 10.1111/all.13718 en
dc.description.abstract The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome. en
dc.description.sponsorship National Institute for Health Research (Grant Number: IS‐BRC‐1215‐20006); Foundation for the National Institutes of Health (Grant Numbers: R01 CA181115, R01CA196266, R01CA196266‐01A1:S1, R03CA173842); Deutsche Forschungsgemeinschaft (Grant Number: HA 2393/6‐1); Departament de Salut, Generalitat de Catalunya (Grant Number: SLT002/16/00232); Austrian Science Fund (Grant Numbers: F4606‐B28, KLI284, P23398‐B11); Cancer Research UK (Grant Numbers: C30122/A11527, C30122/A15774); Israel Science Foundation (Grant Number: #213/05); Israel Cancer Association (Grant Number: #20161131); Breast Cancer Now (Grant Number: C10355/A15587); Israel Science Foundation “Center of Excellence /MOKED”; en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Wiley en
dc.relation.uri https://onlinelibrary.wiley.com/doi/full/10.1111/all.13718
dc.rights © 2019 The Authors. Allergy Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. en
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ en
dc.subject Allergy en
dc.subject Cancer en
dc.subject Hygience hypothesis en
dc.subject Microbiota en
dc.subject Oncoimmunology en
dc.title AllergoOncology: microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Liam O Mahony, Department of Medicine and Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland. +353-21-490-3000 Email:liam.omahony@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder National Institute for Health Research en
dc.contributor.funder European Academy of Allergy and Clinical Immunology en
dc.contributor.funder Foundation for the National Institutes of Health en
dc.contributor.funder Deutsche Forschungsgemeinschaft en
dc.contributor.funder Aimwell Charitable Trust and Emailie Gutterman Memorial Endowed Fund en
dc.contributor.funder Departament de Salut, Generalitat de Catalunya en
dc.contributor.funder IGEM Therapeutics Ltd en
dc.contributor.funder Austrian Science Fund en
dc.contributor.funder Instytut Biologii Medycznej Polskiej Akademii Nauk en
dc.contributor.funder Cancer Research UK en
dc.contributor.funder Medical Research Council en
dc.contributor.funder Israel Science Foundation en
dc.contributor.funder Israel Cancer Association en
dc.contributor.funder American Society of Hematology en
dc.contributor.funder Breast Cancer Now en
dc.contributor.funder Stop Cancer en
dc.contributor.funder Israel Ministry of Science, Technology and Space “Personalized Medicine” en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Allergy: European Journal of Allergy and Clinical Immunology en
dc.internal.IRISemailaddress liam.omahony@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/RCUK/MRC/MR/L023091/1/GB/Preclinical efficacy of an antibody of the IgE class against a melanoma-associated antigen/ en


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© 2019 The Authors. Allergy Published by John Wiley & Sons Ltd.  This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Except where otherwise noted, this item's license is described as © 2019 The Authors. Allergy Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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