dc.contributor.author	Flemer, Burkhardt
dc.contributor.author	Warren, Ryan D.
dc.contributor.author	Barrett, Maurice P. J.
dc.contributor.author	Cisek, Katryna
dc.contributor.author	Das, Anubhav
dc.contributor.author	Jeffery, Ian B.
dc.contributor.author	Hurley, Eimear
dc.contributor.author	O'Riordain, Micheal
dc.contributor.author	Shanahan, Fergus
dc.contributor.author	O'Toole, Paul W.
dc.contributor.funder	Science Foundation Ireland
dc.date.accessioned	2017-12-08T13:33:44Z
dc.date.available	2017-12-08T13:33:44Z
dc.date.issued	2017-10-07
dc.description.abstract	Background and aims: Microbiota alterations are linked with colorectal cancer (CRC) and notably higher abundance of putative oral bacteria on colonic tumours. However, it is not known if colonic mucosa-associated taxa are indeed orally derived, if such cases are a distinct subset of patients or if the oral microbiome is generally suitable for screening for CRC. Methods: We profiled the microbiota in oral swabs, colonic mucosae and stool from individuals with CRC (99 subjects), colorectal polyps (32) or controls (103). Results: Several oral taxa were differentially abundant in CRC compared with controls, for example, Streptococcus and Prevotellas pp. A classification model of oral swab microbiota distinguished individuals with CRC or polyps from controls (sensitivity: 53% (CRC)/67% (polyps); specificity: 96%). Combining the data from faecal microbiota and oral swab microbiota increased the sensitivity of this model to 76% (CRC)/88% (polyps). We detected similar bacterial networks in colonic microbiota and oral microbiota datasets comprising putative oral biofilm forming bacteria. While these taxa were more abundant in CRC, core networks between pathogenic, CRC-associated oral bacteria such as Peptostreptococcus, Parvimonas and Fusobacterium were also detected in healthy controls. High abundance of Lachnospiraceae was negatively associated with the colonisation of colonic tissue with oral-like bacterial networks suggesting a protective role for certain microbiota types against CRC, possibly by conferring colonisation resistance to CRC-associated oral taxa and possibly mediated through habitual diet. Conclusion: The heterogeneity of CRC may relate to microbiota types that either predispose or provide resistance to the disease, and profiling the oral microbiome may offer an alternative screen for detecting CRC.	en
dc.description.sponsorship	Science Foundation Ireland (APC Microbiome Institute (APC/SFI/12/RC/2273); 13/SIRG/2128)	en
dc.description.status	Peer reviewed	en
dc.description.version	Published Version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Flemer, B., Warren, R. D., Barrett, M. P., Cisek, K., Das, A., Jeffery, I. B., Hurley, E., O’Riordain, M., Shanahan, F. and O’Toole, P. W. (2017) 'The oral microbiota in colorectal cancer is distinctive and predictive', Gut, pp. 1-11 doi: 10.1136/gutjnl-2017-314814	en
dc.identifier.doi	10.1136/gutjnl-2017-314814
dc.identifier.endpage	11
dc.identifier.issn	0017-5749
dc.identifier.issn	1468-3288
dc.identifier.journaltitle	Gut	en
dc.identifier.startpage	1
dc.identifier.uri	https://hdl.handle.net/10468/5143
dc.language.iso	en	en
dc.publisher	BMJ Publishing Group	en
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.project	info:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/13/SIRG/2128/IE/Development of Knowledge Base Necessary for Novel Diagnostic and Therapeutic Pipeline for the Early Identification and Treatment of Rheumatoid Arthritis/
dc.relation.uri	http://gut.bmj.com/content/early/2017/10/07/gutjnl-2017-314814
dc.rights	© 2017, the Authors, unless otherwise stated in the text of the article. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/	en
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/
dc.subject	Gut microbiota	en
dc.subject	Colorectal cancer	en
dc.subject	CRC	en
dc.subject	Fusobacterium nucleatum	en
dc.subject	Oral bacteria	en
dc.title	The oral microbiota in colorectal cancer is distinctive and predictive	en
dc.type	Article (peer-reviewed)	en

The oral microbiota in colorectal cancer is distinctive and predictive

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