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No effect of a musical intervention on stress response to venepuncture in a neonatal population
Powell, Anna S.
Boylan, Geraldine B.
Aim: To investigate the effect of a musical intervention on neonatal stress response to venepuncture as measured by salivary cortisol levels and pain profile scores. Methods: In a randomised control crossover trial, participants were randomised to both a control arm (sucrose) and intervention arm (sucrose and music) for routine venepuncture procedures. Salivary swabs were collected at baseline, 20 minutes post‐venepuncture and 4 hours post‐venepuncture. Pain levels were assessed using the Premature Infant Pain Profile (PIPP). A total of 16 preterm neonates participated in both arms to complete the study. Results: Cortisol values were elevated at all timepoints in the intervention arm (baseline, 20 minutes, and 4 hours post‐procedure) but not significantly so (P = .056, P = .3, and P = .575, respectively). Median change in cortisol values from baseline was +128.48 pg/mL (−47.66 to 517.02) at 20 minutes and +393.52 pg/mL (47.88‐1221.34) at 4 hours post‐procedure in the control arm compared to −69.564 pg/mL (−860.96 to 397.289) and +100.48 pg/mL (−560.46 to 842.99) at 20 minutes and 4 hours post‐procedure in the intervention arm. There was no statistically significant difference observed between groups (P = .311 at 20 minutes, and P = .203 at 4 hours post‐procedure). PIPP scores were not significantly different between study arms. Conclusion: Our findings did not support the additional benefit of music intervention on neonatal stress response to venepuncture in preterm infants.
Cortisol , Music intervention , Neonatology , Intensive-care , Heel-lance , Premature-infant , Procedural pain , Preterm , Management , Efficacy , Relief
Howard, C., Powell, Anna S., Pavlidis, E., Pavel, A., Finn, D., Allen, A., Olavarria-Ramirez, L., Clarke, G., Livingstone, V., Boylan, G. B. and Dempsey, E. M. (2020) 'No effect of a musical intervention on stress response to venepuncture in a neonatal population', Acta Paediatrica, 109, pp. 511-517. doi: 10.1111/apa.15018
© 2019 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Howard, C, Powell, AS, Pavlidis, E, et al. No effect of a musical intervention on stress response to venepuncture in a neonatal population. Acta Paediatr. 2020; 109: 511– 517, which has been published in final form at https://doi.org/10.1111/apa.15018. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.