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Advanced glycation end product intake during pregnancy and offspring allergy outcomes: prospective cohort study
Smith, Pete K.
Palumbo, Michaela P.
Ben Abdallah, Miriam
John Wiley & Sons, Inc.
Background: Associations have been shown between concurrent assessment of dietary intake of AGEs and childhood allergic outcomes. We examined the association between maternal AGEs intake and development of offspring asthma, wheeze, atopic dermatitis, allergic rhinitis, and food allergies, and sought to determine whether intake of AGEs was associated with cord sera cytokines/chemokines. Methods: Pregnant women ≥ 16 years were recruited in the Healthy Start study, a prospective pre-birth cohort from Colorado (N =1410). The analysis included 962 dyads with adequate diet (≥2 recalls) and allergy outcome details. AGEs intake was estimated for each mother by matching intakes reported using 24-hour dietary recalls during pregnancy to a reference database of commonly consumed foods’ AGEs values. Child diagnoses of asthma and allergies up to 8 years were obtained from electronic medical records. Cord sera cytokines and chemokines were analyzed in a subset (N = 462) of children. Results: The median [IQR] AGEs intake for the overall sample was 11919 kU/day [8293, 16573]. Unadjusted analysis showed a positive association between maternal AGEs intake in pregnancy and rhinitis up to 8 years of age (HR = 1.03; 95% CI: 1.01, 1.06), but the association was attenuated and no longer significant in adjusted models (HR = 1.01; 95% CI: 0.98, 1.04). Both adjusted and unadjusted models showed no associations between AGEs intake in pregnancy and any of the other outcomes (p>0.05). There were no significant associations between any cytokine or chemokine measured and AGEs intake or any of the outcomes studied (p>0.05). Conclusion: The study showed that maternal AGEs intake was not associated with offspring asthma and allergy outcomes. AGEs exposure during pregnancy may not have the same impact on child development to postnatal exposure.
AGE , Allergies , Maternal AGEs intake , Cord sera cytokines/chemokines
Venter, C., Pickett , K., Starling, A., Maslin, K., Smith, P. K., Palumbo, M. P., O'Mahony, L., Ben Abdallah, M. and Dabelea, D. (2021) 'Advanced glycation end product intake during pregnancy and offspring allergy outcomes: prospective cohort study', Clinical and Experimental Allergy. doi: 10.1111/cea.14027
© 2021, John Wiley & Sons, Inc. This is the peer reviewed version of the following item: Venter, C., Pickett , K., Starling, A., Maslin, K., Smith, P. K., Palumbo, M. P., O'Mahony, L., Ben Abdallah, M. and Dabelea, D. (2021) 'Advanced glycation end product intake during pregnancy and offspring allergy outcomes: prospective cohort study', Clinical and Experimental Allergy, doi: 10.1111/cea.14027, which has been published in final form at https://doi.org/10.1111/cea.14027. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.