Advanced glycation end product intake during pregnancy and offspring allergy outcomes: prospective cohort study

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dc.contributor.authorVenter, Carina
dc.contributor.authorPickett, Kaci
dc.contributor.authorStarling, Anne
dc.contributor.authorMaslin, Kate
dc.contributor.authorSmith, Pete K.
dc.contributor.authorPalumbo, Michaela P.
dc.contributor.authorO'Mahony, Liam
dc.contributor.authorBen Abdallah, Miriam
dc.contributor.authorDabelea, Dana
dc.contributor.funderNational Institutes of Healthen
dc.contributor.funderNational Institute of Diabetes and Digestive and Kidney Diseasesen
dc.date.accessioned2021-10-11T14:37:52Z
dc.date.available2021-10-11T14:37:52Z
dc.date.issued2021-10-05
dc.date.updated2021-10-11T14:14:26Z
dc.description.abstractBackground: Associations have been shown between concurrent assessment of dietary intake of AGEs and childhood allergic outcomes. We examined the association between maternal AGEs intake and development of offspring asthma, wheeze, atopic dermatitis, allergic rhinitis, and food allergies, and sought to determine whether intake of AGEs was associated with cord sera cytokines/chemokines. Methods: Pregnant women ≥ 16 years were recruited in the Healthy Start study, a prospective pre-birth cohort from Colorado (N =1410). The analysis included 962 dyads with adequate diet (≥2 recalls) and allergy outcome details. AGEs intake was estimated for each mother by matching intakes reported using 24-hour dietary recalls during pregnancy to a reference database of commonly consumed foods’ AGEs values. Child diagnoses of asthma and allergies up to 8 years were obtained from electronic medical records. Cord sera cytokines and chemokines were analyzed in a subset (N = 462) of children. Results: The median [IQR] AGEs intake for the overall sample was 11919 kU/day [8293, 16573]. Unadjusted analysis showed a positive association between maternal AGEs intake in pregnancy and rhinitis up to 8 years of age (HR = 1.03; 95% CI: 1.01, 1.06), but the association was attenuated and no longer significant in adjusted models (HR = 1.01; 95% CI: 0.98, 1.04). Both adjusted and unadjusted models showed no associations between AGEs intake in pregnancy and any of the other outcomes (p>0.05). There were no significant associations between any cytokine or chemokine measured and AGEs intake or any of the outcomes studied (p>0.05). Conclusion: The study showed that maternal AGEs intake was not associated with offspring asthma and allergy outcomes. AGEs exposure during pregnancy may not have the same impact on child development to postnatal exposure.en
dc.description.sponsorshipNational Institutes of Health (R01 DK076648/DK/NIDDK NIH HHS/United States; R01 GM121081/GM/NIGMS NIH HHS/United States; UG3 OD023248/OD/NIH HHS/United States; UH3 OD023248/OD/NIH HHS/United States; R25GM111901-S1; R25GM11190; R00ES025817)en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationVenter, C., Pickett , K., Starling, A., Maslin, K., Smith, P. K., Palumbo, M. P., O'Mahony, L., Ben Abdallah, M. and Dabelea, D. (2021) 'Advanced glycation end product intake during pregnancy and offspring allergy outcomes: prospective cohort study', Clinical and Experimental Allergy. doi: 10.1111/cea.14027en
dc.identifier.doi10.1111/cea.14027en
dc.identifier.eissn1365-2222
dc.identifier.issn0954-7894
dc.identifier.journaltitleClinical and Experimental Allergyen
dc.identifier.urihttps://hdl.handle.net/10468/12081
dc.language.isoenen
dc.publisherJohn Wiley & Sons, Inc.en
dc.rights© 2021, John Wiley & Sons, Inc. This is the peer reviewed version of the following item: Venter, C., Pickett , K., Starling, A., Maslin, K., Smith, P. K., Palumbo, M. P., O'Mahony, L., Ben Abdallah, M. and Dabelea, D. (2021) 'Advanced glycation end product intake during pregnancy and offspring allergy outcomes: prospective cohort study', Clinical and Experimental Allergy, doi: 10.1111/cea.14027, which has been published in final form at https://doi.org/10.1111/cea.14027. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en
dc.subjectAGEen
dc.subjectAllergiesen
dc.subjectMaternal AGEs intakeen
dc.subjectCord sera cytokines/chemokinesen
dc.titleAdvanced glycation end product intake during pregnancy and offspring allergy outcomes: prospective cohort studyen
dc.typeArticle (peer-reviewed)en
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