Short chain fatty acids: microbial metabolites for gut-brain axis signalling

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dc.contributor.authorO'Riordan, Kenneth J.
dc.contributor.authorCollins, Michael K.
dc.contributor.authorMoloney, Gerard M.
dc.contributor.authorKnox, Emily G.
dc.contributor.authorAburto, Maria Rodriguez
dc.contributor.authorFulling, Christine
dc.contributor.authorMorley, Shane J.
dc.contributor.authorClarke, Gerard
dc.contributor.authorSchellekens, Harriƫt
dc.contributor.authorCryan, John F.
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderSaks-Kavanaugh Foundationen
dc.contributor.funderHorizon 2020en
dc.contributor.funderSchweizerischer Nationalfonds zur Fƶrderung der Wissenschaftlichen Forschungen
dc.contributor.funder4D Pharmaen
dc.contributor.funderCremoen
dc.contributor.funderDuPonten
dc.contributor.funderMead Johnson Nutritionen
dc.contributor.funderPharmaviteen
dc.date.accessioned2022-04-05T12:22:07Z
dc.date.available2022-04-05T12:22:07Z
dc.date.issued2022-04
dc.date.updated2022-04-05T11:31:20Z
dc.description.abstractThe role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the brain will be critical for the subsequent development of new therapeutic approaches, including the identification of novel psychobiotics. A key focus in this regard have been the short-chain fatty acids (SCFAs) produced by bacterial fermentation of dietary fibre, which include butyrate, acetate, and propionate. Ongoing research is focused on the entry of SCFAs into systemic circulation from the gut lumen, their migration to cerebral circulation and across the blood brain barrier, and their potential to exert acute and chronic effects on brain structure and function. This review aims to discuss our current mechanistic understanding of the direct and indirect influence that SCFAs have on brain function, behaviour and physiology, which will inform future microbiota-targeted interventions for brain disorders.en
dc.description.sponsorshipSwiss National Science Foundation (Project CRSII5_186346/NMS2068)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid111572en
dc.identifier.citationO'Riordan, K. J., Collins M. K., Moloney, G. M., Knox, E. G., Aburto, M. R., Fulling, C., Morley, S. J., Clarke, G., Schellekens, H. and Cryan, J. F. (2022) 'Short chain fatty acids: microbial metabolites for gut-brain axis signalling', Molecular and Cellular Endocrinology, 546, 111572 (18pp). doi: 10.1016/j.mce.2022.111572en
dc.identifier.doi10.1016/j.mce.2022.111572en
dc.identifier.endpage18en
dc.identifier.issn1872-8057
dc.identifier.journaltitleMolecular and Cellular Endocrinologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/13032
dc.identifier.volume546en
dc.language.isoenen
dc.publisherElsevier B. V.en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/EC/H2020::RIA/848228/EU/Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe/DISCOvERIEen
dc.rightsĀ© 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMicrobiota-gut-brain axisen
dc.subjectMicrobiotaen
dc.subjectMicrobiomeen
dc.subjectShort-chain fatty acidsen
dc.titleShort chain fatty acids: microbial metabolites for gut-brain axis signallingen
dc.typeArticle (peer-reviewed)en
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