Maternal hypertensive disorders of pregnancy and depression or anxiety in adolescence: Findings from the Millennium Cohort Study

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dc.check.date2024-11-18en
dc.check.infoAccess to this item is restricted for 12 months at the request of the publisher
dc.contributor.authorKeenan, Martinen
dc.contributor.authorKhashan, Ali S.en
dc.contributor.authorO'Byrne, Laura J.en
dc.contributor.authorO'Keeffe, Gerard W.en
dc.contributor.authorAl Khalaf, Sukainahen
dc.contributor.authorMaher, Gillian M.en
dc.date.accessioned2024-05-15T11:56:37Z
dc.date.available2024-05-15T11:56:37Z
dc.date.issued2023-11-18en
dc.description.abstractBackground: The short-term effects of hypertensive disorders of pregnancy (HDP) on the health of the fetus are well known; however, their impacts on the risk of mental health in the exposed offspring are not fully understood. Our aim was to examine the association between HDP and depression/anxiety at age 17 years. Methods: We used data from The Millennium Cohort Study, a nationally representative longitudinal study of children born in the United Kingdom. Data on HDP and potential confounders were collected when children were 9-months. Data on depression and anxiety were collected as one variable when children were aged 17 years using self-reported doctor diagnosis, and reclassified as depression/anxiety (overall), depression/anxiety with treatment, and depression/anxiety without treatment. Crude and adjusted logistic regression models were performed to examine the association between HDP and depression/anxiety, adjusting for several maternal and socio-economic factors. Results: There were 9517 singleton mother-child pairs included in the analyses. Adjusted logistic regression suggested an association between HDP and depression/anxiety (adjusted odds ratio, (aOR):1.30 [95 % CI, 1.02–1.66]) at age 17 years. A similar association was observed for HDP and depression/anxiety with treatment (aOR:1.33 [95 % CI, 1.01–1.73]) and HDP and depression/anxiety without treatment (aOR: 1.30 [95 % CI, 0.80–2.12]), although the latter did not reach statistical significance. Limitations: Data on severity and classifications of HDP were not available. Conclusion: Exposure to HDP may be associated with an increased likelihood of depression or anxiety at age 17 years. Future research should consider severity and different classifications of HDP.en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationKeenan, M., Khashan, A.S., O’Byrne, L.J., O’Keeffe, G.W., Al Khalaf, S. and Maher, G.M. (2024) ‘Maternal hypertensive disorders of pregnancy and depression or anxiety in adolescence: Findings from the Millennium Cohort Study’, Journal of Affective Disorders, 347, pp. 23–28. Available at: https://doi.org/10.1016/j.jad.2023.11.042en
dc.identifier.doihttps://doi.org/10.1016/j.jad.2023.11.042en
dc.identifier.endpage28en
dc.identifier.issn0165-0327en
dc.identifier.journaltitleJournal of Affective Disordersen
dc.identifier.startpage23en
dc.identifier.urihttps://hdl.handle.net/10468/15869
dc.identifier.volume347en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofJournal of Affective Disordersen
dc.rights© 2023 Elsevier B. V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectAdolescenceen
dc.subjectAnxietyen
dc.subjectDepressionen
dc.subjectHypertensionen
dc.subjectHypertensionen
dc.subjectHypertensive disorders of pregnancyen
dc.subjectPregnancyen
dc.titleMaternal hypertensive disorders of pregnancy and depression or anxiety in adolescence: Findings from the Millennium Cohort Studyen
dc.typeArticle (peer-reviewed)en
oaire.citation.volume347en
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