Maternal hypertensive disorders of pregnancy and depression or anxiety in adolescence: Findings from the Millennium Cohort Study
dc.check.date | 2024-11-18 | en |
dc.check.info | Access to this item is restricted for 12 months at the request of the publisher | |
dc.contributor.author | Keenan, Martin | en |
dc.contributor.author | Khashan, Ali S. | en |
dc.contributor.author | O'Byrne, Laura J. | en |
dc.contributor.author | O'Keeffe, Gerard W. | en |
dc.contributor.author | Al Khalaf, Sukainah | en |
dc.contributor.author | Maher, Gillian M. | en |
dc.date.accessioned | 2024-05-15T11:56:37Z | |
dc.date.available | 2024-05-15T11:56:37Z | |
dc.date.issued | 2023-11-18 | en |
dc.description.abstract | Background: The short-term effects of hypertensive disorders of pregnancy (HDP) on the health of the fetus are well known; however, their impacts on the risk of mental health in the exposed offspring are not fully understood. Our aim was to examine the association between HDP and depression/anxiety at age 17 years. Methods: We used data from The Millennium Cohort Study, a nationally representative longitudinal study of children born in the United Kingdom. Data on HDP and potential confounders were collected when children were 9-months. Data on depression and anxiety were collected as one variable when children were aged 17 years using self-reported doctor diagnosis, and reclassified as depression/anxiety (overall), depression/anxiety with treatment, and depression/anxiety without treatment. Crude and adjusted logistic regression models were performed to examine the association between HDP and depression/anxiety, adjusting for several maternal and socio-economic factors. Results: There were 9517 singleton mother-child pairs included in the analyses. Adjusted logistic regression suggested an association between HDP and depression/anxiety (adjusted odds ratio, (aOR):1.30 [95 % CI, 1.02–1.66]) at age 17 years. A similar association was observed for HDP and depression/anxiety with treatment (aOR:1.33 [95 % CI, 1.01–1.73]) and HDP and depression/anxiety without treatment (aOR: 1.30 [95 % CI, 0.80–2.12]), although the latter did not reach statistical significance. Limitations: Data on severity and classifications of HDP were not available. Conclusion: Exposure to HDP may be associated with an increased likelihood of depression or anxiety at age 17 years. Future research should consider severity and different classifications of HDP. | en |
dc.description.status | Peer reviewed | en |
dc.description.version | Accepted Version | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Keenan, M., Khashan, A.S., O’Byrne, L.J., O’Keeffe, G.W., Al Khalaf, S. and Maher, G.M. (2024) ‘Maternal hypertensive disorders of pregnancy and depression or anxiety in adolescence: Findings from the Millennium Cohort Study’, Journal of Affective Disorders, 347, pp. 23–28. Available at: https://doi.org/10.1016/j.jad.2023.11.042 | en |
dc.identifier.doi | https://doi.org/10.1016/j.jad.2023.11.042 | en |
dc.identifier.endpage | 28 | en |
dc.identifier.issn | 0165-0327 | en |
dc.identifier.journaltitle | Journal of Affective Disorders | en |
dc.identifier.startpage | 23 | en |
dc.identifier.uri | https://hdl.handle.net/10468/15869 | |
dc.identifier.volume | 347 | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.relation.ispartof | Journal of Affective Disorders | en |
dc.rights | © 2023 Elsevier B. V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.subject | Adolescence | en |
dc.subject | Anxiety | en |
dc.subject | Depression | en |
dc.subject | Hypertension | en |
dc.subject | Hypertension | en |
dc.subject | Hypertensive disorders of pregnancy | en |
dc.subject | Pregnancy | en |
dc.title | Maternal hypertensive disorders of pregnancy and depression or anxiety in adolescence: Findings from the Millennium Cohort Study | en |
dc.type | Article (peer-reviewed) | en |
oaire.citation.volume | 347 | en |
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