A Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial

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dc.contributor.authorJennings, Amy
dc.contributor.authorCashman, Kevin D.
dc.contributor.authorGillings, Rachel
dc.contributor.authorCassidy, Aedin
dc.contributor.authorTang, Jonathan
dc.contributor.authorFraser, William
dc.contributor.authorDowling, Kirsten G.
dc.contributor.authorHull, George L. J.
dc.contributor.authorBerendsen, Agnes A. M.
dc.contributor.authorde Groot, Lisette C. P. G. M.
dc.contributor.authorPietruszka, Barbara
dc.contributor.authorWierzbicka, Elzbieta
dc.contributor.authorOstan, Rita
dc.contributor.authorBazzocchi, Alberto
dc.contributor.authorBattista, Giuseppe
dc.contributor.authorCaumon, Elodie
dc.contributor.authorMeunier, Nathalie
dc.contributor.authorMalpuech-Brugère, Corinne
dc.contributor.authorFranceschi, Claudio
dc.contributor.authorSantoro, Aurelia
dc.contributor.authorFairweather-Tait, Susan J.
dc.date.accessioned2018-09-27T12:08:17Z
dc.date.available2018-09-27T12:08:17Z
dc.date.issued2018
dc.description.abstractBackground: The Mediterranean diet (MD) is widely recommended for the prevention of chronic disease, but evidence for a beneficial effect on bone health is lacking. Objective: The aim of this study was to examine the effect of a Mediterranean-like dietary pattern [NU-AGE (New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe)] on indexes of inflammation with a number of secondary endpoints, including bone mineral density (BMD) and biomarkers of bone and collagen degradation in a 1-y multicenter randomized controlled trial (RCT; NU-AGE) in elderly Europeans. Design: An RCT was undertaken across 5 European centers. Subjects in the intervention group consumed the NU-AGE diet for 1 y by receiving individually tailored dietary advice, coupled with supplies of foods including whole-grain pasta, olive oil, and a vitamin D3 supplement (10 µg/d). Participants in the control group were provided with leaflets on healthy eating available in their country. Results: A total of 1294 participants (mean ± SD age: 70.9 ±4.0 y; 44% male) were recruited to the study and 1142 completed the 1-y trial. The Mediterranean-like dietary pattern had no effect on BMD (site-specific or whole-body); the inclusion of compliance to the intervention in the statistical model did not change the findings. There was also no effect of the intervention on the urinary biomarkers free pyridinoline or free deoxypyridinoline. Serum 25-hydroxyvitamin D significantly increased and parathyroid hormone decreased (P < 0.001) in the MD compared with the control group. Subgroup analysis of individuals with osteoporosis at baseline (site-specific BMD T-score ≤ −2.5 SDs) showed that the MD attenuated the expected decline in femoral neck BMD (n = 24 and 30 in MD and control groups, respectively; P = 0.04) but had no effect on lumbar spine or whole-body BMD. Conclusions: A 1-y intervention of the Mediterranean-like diet together with vitamin D3 supplements (10 µg/d) had no effect on BMD in the normal age-related range, but it significantly reduced the rate of loss of bone at the femoral neck in individuals with osteoporosis. The NU-AGE trial is registered at clinicaltrials.gov as NCT01754012.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleidnyq22
dc.identifier.citationJennings, A., Cashman, K. D., Gillings, R., Cassidy, A., Tang, J., Fraser, W., Dowling, K. G., Hull, G. L. J., Berendsen, A. A. M., de Groot, L. C. P. G. M., Pietruszka, B., Wierzbicka, E., Ostan, R., Bazzocchi, A., Battista, G., Caumon, E., Meunier, N., Malpuech-Brugère, C., Franceschi, C., Santoro, A. and Fairweather-Tait, S. J. (2018) 'A Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial', The American Journal of Clinical Nutrition, nqy122 (8pp). doi: 10.1093/ajcn/nqy122en
dc.identifier.doi10.1093/ajcn/nqy122
dc.identifier.endpage8
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.journaltitleAmerican Journal of Clinical Nutritionen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6932
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urihttps://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqy122/5051862
dc.rights© 2018, American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectOsteoporosisen
dc.subjectBoneen
dc.subjectMediterranean dieten
dc.subjectVitamin D supplementationen
dc.subjectOlder adultsen
dc.titleA Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trialen
dc.typeArticle (peer-reviewed)en
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