Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial

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dc.contributor.authorCronin, Owen
dc.contributor.authorBarton, Wiley
dc.contributor.authorMoran, Carthage
dc.contributor.authorSheehan, Donal
dc.contributor.authorWhiston, Ronan
dc.contributor.authorNugent, Helena
dc.contributor.authorMcCarthy, Yvonne
dc.contributor.authorMolloy, Catherine B.
dc.contributor.authorO'Sullivan, Orla
dc.contributor.authorCotter, Paul D.
dc.contributor.authorMolloy, Michael G.
dc.contributor.authorShanahan, Fergus
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderIrish Centre for Arthritis Research and Education, Ireland
dc.date.accessioned2019-11-26T05:06:40Z
dc.date.available2019-11-26T05:06:40Z
dc.date.issued2019-02-12
dc.description.abstractBackground: Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease. Methods: A randomized, cross-over trial of eight weeks combined aerobic and resistance training on body composition assessed by Dual Energy X-ray Absorptiometry was performed. Patients in clinical remission and physically inactive with a mean age of 25 ± 6.5 years and Body Mass Index of 28.9 ± 3.8 were recruited from a dedicated Inflammatory Bowel Disease clinic. Serum cytokines were quantified, and microbiota assessed using metagenomic sequencing. Results: Improved physical fitness was demonstrated in the exercise group by increases in median estimated VO2max (Baseline: 43.41mls/kg/min; post-intervention: 46.01mls/kg/min; p = 0.03). Improvement in body composition was achieved by the intervention group (n = 13) with a median decrease of 2.1% body fat compared with a non-exercising group (n = 7) (0.1% increase; p = 0.022). Lean tissue mass increased by a median of 1.59 kg and fat mass decreased by a median of 1.52 kg in the exercising group. No patients experienced a deterioration in disease activity scores during the exercise intervention. No clinically significant alterations in the α- and β-diversity of gut microbiota and associated metabolic pathways were evident. Conclusions: Moderate-intensity combined aerobic and resistance training is safe in physically unfit patients with quiescent Inflammatory Bowel Disease and can quickly achieve favourable body compositional changes without adverse effects.en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid29en
dc.identifier.citationCronin, O., Barton, W., Moran, C., Sheehan, D., Whiston, R., Nugent, H., McCarthy, Y., Molloy, C.B., O’Sullivan, O., Cotter, P.D., Molloy, M.G. and Shanahan F. (2019) 'Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial' BMC Gastroenterology, 19(1), 29. (11pp) doi:10.1186/s12876-019-0952-xen
dc.identifier.doi10.1186/s12876-019-0952-xen
dc.identifier.eissn1471-230X
dc.identifier.endpage11en
dc.identifier.issued1en
dc.identifier.journaltitleBMC Gastroenterologyen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/9223
dc.identifier.volume19en
dc.language.isoenen
dc.publisherBioMed Central Ltden
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/11/PI/1137/IE/Obesibiotics/en
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Starting Investigator Research Grant (SIRG)/13/SIRG/2160/IE/Investigating the impact of high intensity exercise and/or protein intake levels on gut microbial diversity./en
dc.relation.urihttps://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-019-0952-x
dc.rights© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectClinical trialsen
dc.subjectMicrobiomeen
dc.subjectExerciseen
dc.subjectBody compositionen
dc.titleModerate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trialen
dc.typeArticle (peer-reviewed)en
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