Bioaccessibility and bioavailability of a marine-derived multimineral, Aquamin-Magnesium

dc.contributor.authorFelice, Valeria D.
dc.contributor.authorO'Gorman, Denise M.
dc.contributor.authorO'Brien, Nora M.
dc.contributor.authorHyland, Niall P.
dc.contributor.funderMarigot Ltd
dc.contributor.funderIrish Research Council
dc.contributor.funderScience Foundation Ireland
dc.date.accessioned2018-09-27T12:08:19Z
dc.date.available2018-09-27T12:08:19Z
dc.date.issued2018
dc.description.abstractIntroduction: Magnesium is an essential mineral involved in a range of key biochemical pathways. Several magnesium supplements are present on the market and their degree of bioavailability differs depending on the form of magnesium salt used. Aquamin-Mg is a natural source of magnesium, containing 72 additional trace minerals derived from the clean waters off the Irish coast. However, the in vitro bioaccessibility and bioavailability of Aquamin-Mg in comparison with other supplement sources of magnesium has yet to be tested. Method: Aquamin-Mg, magnesium chloride (MgCl2) and magnesium oxide (MgO) were subjected to gastrointestinal digestion according to the harmonized INFOGEST in vitro digestion method and in vitro bioavailability tested using the Caco-2 cell model. Magnesium concentration was measured by atomic absorption spectrophotometry (AAS). Results: Magnesium recovery from both Aquamin-Mg and MgCl2 was greater than for MgO. Magnesium from all three sources was transported across the epithelial monolayer with Aquamin-Mg displaying a comparable profile to the more bioavailable MgCl2. Conclusions: Our data support that magnesium derived from a marine-derived multimineral product is bioavailable to a significantly greater degree than MgO and displays a similar profile to the more bioavailable MgCl2 and may offer additional health benefits given its multimineral profile.en
dc.description.sponsorshipIrish Research Council (Enterprise Partnership Scheme Postdoctoral Fellowship, EPSPD/2015/52);en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid912
dc.identifier.citationFelice, V., O’Gorman, D., O’Brien, N. and Hyland, N. (2018) 'Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium', Nutrients, 10(7), 912 (8pp). doi: 10.3390/nu10070912en
dc.identifier.doi10.3390/nu10070912
dc.identifier.endpage8
dc.identifier.issn2072-6643
dc.identifier.issued7
dc.identifier.journaltitleNutrientsen
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/10468/6935
dc.identifier.volume10
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.projectinfo:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/
dc.relation.urihttp://www.mdpi.com/2072-6643/10/7/912
dc.rights© 2018, the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAquaminen
dc.subjectMultimineral supplementen
dc.subjectMagnesium bioavailabilityen
dc.titleBioaccessibility and bioavailability of a marine-derived multimineral, Aquamin-Magnesiumen
dc.typeArticle (peer-reviewed)en
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