A systematic review of the psychobiological burden of informal caregiving for patients with dementia: focus on cognitive and biological markers of chronic stress

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dc.contributor.authorAllen, Andrew P.
dc.contributor.authorCurran, Eileen A.
dc.contributor.authorDuggan, Áine
dc.contributor.authorCryan, John F.
dc.contributor.authorNí Chorcoráin, Aoife
dc.contributor.authorDinan, Timothy G.
dc.contributor.authorMolloy, D. William
dc.contributor.authorKearney, Patricia M.
dc.contributor.authorClarke, Gerard
dc.contributor.funderScience Foundation Irelanden
dc.contributor.funderHealth Research Boarden
dc.date.accessioned2017-01-06T12:07:32Z
dc.date.available2017-01-06T12:07:32Z
dc.date.issued2016-12-13
dc.date.updated2017-01-06T11:54:39Z
dc.description.abstractAs the physiological impact of chronic stress is difficult to study in humans, naturalistic stressors are invaluable sources of information in this area. This review systematically evaluates the research literature examining biomarkers of chronic stress, including neurocognition, in informal dementia caregivers. We identified 151 papers for inclusion in the final review, including papers examining differences between caregivers and controls as well as interventions aimed at counteracting the biological burden of chronic caregiving stress. Results indicate that cortisol was increased in caregivers in a majority of studies examining this biomarker. There was mixed evidence for differences in epinephrine, norepinephrine and other cardiovascular markers. There was a high level of heterogeneity in immune system measures. Caregivers performed more poorly on attention and executive functioning tests. There was mixed evidence for memory performance. Interventions to reduce stress improved cognition but had mixed effects on cortisol. Risk of bias was generally low to moderate. Given the rising need for family caregivers worldwide, the implications of these findings can no longer be neglected.en
dc.description.sponsorshipHealth Research Board, Ireland (HRB Health Research Awards (grant number HRA POR 2014 647)); Science Foundation Ireland (SFI grant number SFI/12/RC/2273).en
dc.description.statusPeer revieweden
dc.description.versionAccepted Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAllen, A. P., Curran, E. A., Duggan, Á., Cryan, J. F., Chorcoráin, A. N., Dinan, T. G., Molloy, D. W., Kearney, P. M. and Clarke, G. (2017) 'A systematic review of the psychobiological burden of informal caregiving for patients with dementia: Focus on cognitive and biological markers of chronic stress', Neuroscience & Biobehavioral Reviews, 73, pp. 123-164. doi:10.1016/j.neubiorev.2016.12.006en
dc.identifier.doi10.1016/j.neubiorev.2016.12.006
dc.identifier.endpage164en
dc.identifier.issn0149-7634
dc.identifier.journaltitleNeuroscience & Biobehavioral Reviewsen
dc.identifier.startpage123en
dc.identifier.urihttps://hdl.handle.net/10468/3439
dc.identifier.volume73en
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2016 Elsevier Ltd. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 licenseen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectStressen
dc.subjectCaregiveren
dc.subjectDementiaen
dc.subjectCortisolen
dc.subjectImmune systemen
dc.subjectCardiovascularen
dc.subjectEpinephrineen
dc.subjectNorepinephrineen
dc.subjectCognitionen
dc.subjectAttentionen
dc.subjectMemoryen
dc.subjectBiomarkeren
dc.titleA systematic review of the psychobiological burden of informal caregiving for patients with dementia: focus on cognitive and biological markers of chronic stressen
dc.typeArticle (peer-reviewed)en
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