Associations between ambient particle radioactivity and lung function

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dc.contributor.authorNyhan, Marguerite M.
dc.contributor.authorRice, Mary
dc.contributor.authorBlomberg, Annelise
dc.contributor.authorCoull, Brent A.
dc.contributor.authorGarshick, Eric
dc.contributor.authorVokonas, Pantel
dc.contributor.authorSchwartz, Joel
dc.contributor.authorGold, Diane R.
dc.contributor.authorKoutrakis, Petros
dc.contributor.funderU.S. Environmental Protection Agencyen
dc.contributor.funderNIH (US)en
dc.contributor.funderNational Institute of Environmental Health Sciencesen
dc.contributor.funderU.S. Department of Veterans Affairsen
dc.contributor.funderEpidemiology Research and Information Center (ERIC)en
dc.contributor.funderEpidemiology Research and Information Center (MAVERIC)en
dc.contributor.funderVA Boston Healthcare Systemen
dc.date.accessioned2019-10-29T05:50:47Z
dc.date.available2019-10-29T05:50:47Z
dc.date.issued2019-06-11
dc.description.abstractPrevious studies have suggested increased risk of respiratory diseases and mortality following short-term exposures to ionizing radiation. However, the short-term respiratory effects of low-level environmental radiation associated with air pollution particles have not been considered. Although ambient particulate matter (PM) has been reproducibly linked to decreased lung function and to increased respiratory related morbidity, the properties of PM promoting its toxicity are uncertain. As such, we evaluated whether lung function was associated with exposures to radioactive components of ambient PM, referred to as particle radioactivity (PR). For this, we performed a repeated-measures analysis of 839 men to examine associations between PR exposure and lung function using mixed-effects regression models, adjusting for potential confounders. We examined whether PR-lung function associations changed after adjusting for PM2.5 (particulate matter≤2.5 μm) or black carbon, and vice versa. PR was measured by the USEPA's radiation monitoring network. We found that higher PR exposure was associated with a lower forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1). An IQR increase in 28-day PR exposure was associated with a 2.4% lower FVC [95% confidence interval (CI): 1.4, 3.4% p < 0.001] and a 2.4% lower FEV1 (95% CI: 1.3, 3.5%, p < 0.001). The PR-lung function associations were partially attenuated with adjustment for PM2.5 and black carbon. This is the first study to demonstrate associations between PR and lung function, which were independent of and similar in magnitude to those of PM2.5 and black carbon. If confirmed, future research should account for PR exposure in estimating respiratory health effects of ambient particles. Because of widespread exposure to low levels of ionizing radiation, our findings may have important implications for research, and environmental health policies worldwide.en
dc.description.sponsorshipU.S. Environmental Protection Agency (RD-835872-01); National Institutes of Health (P01-ES009825 and R01-ES019853); National Institute of Environmental Health Sciences (NIEHS) (P30-ES000002); Cooperative Studies Program/Epidemiology Research and Information Center (ERIC) (The Veterans Administration (VA) Normative Aging Study); Department of Veteran Affairs (The Veterans Administration (VA) Normative Aging Study;en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.articleid104795en
dc.identifier.citationNyhan, M.M., Rice, M., Blomberg, A., Coull, B.A., Garshick, E., Vokonas, P., Schwartz, J., Gold, D.R. and Koutrakis, P., 2019. Associations between ambient particle radioactivity and lung function. Environment international, 130, 104795 (8 pp.). DOI:10.1016/j.envint.2019.04.066en
dc.identifier.doi10.1016/j.envint.2019.04.066en
dc.identifier.eissn1873-6750
dc.identifier.endpage8en
dc.identifier.issn0160-4120
dc.identifier.journaltitleEnvironment Internationalen
dc.identifier.startpage1en
dc.identifier.urihttps://hdl.handle.net/10468/8905
dc.identifier.volume130en
dc.language.isoenen
dc.publisherElsevier Ltden
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0160412018321081
dc.rights© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND licenseen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectParticle radioactivityen
dc.subjectLung functionen
dc.subjectEpidemiologyen
dc.subjectParticulate matteren
dc.subjectParticle toxicityen
dc.titleAssociations between ambient particle radioactivity and lung functionen
dc.typeArticle (peer-reviewed)en
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