Impact of exercise on innate immunity in multiple sclerosis progression and symptomatology

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dc.contributor.authorBarry, Alison
dc.contributor.authorCronin, Owen
dc.contributor.authorRyan, Aisling M.
dc.contributor.authorSweeney, Brian
dc.contributor.authorYap, Siew M.
dc.contributor.authorO'Toole, Orna
dc.contributor.authorAllen, Andrew P.
dc.contributor.authorClarke, Gerard
dc.contributor.authorO'Halloran, Ken D.
dc.contributor.authorDowner, Eric J.
dc.contributor.funderUniversity College Corken
dc.contributor.funderTrinity College Dublinen
dc.date.accessioned2017-01-05T10:03:53Z
dc.date.available2017-01-05T10:03:53Z
dc.date.issued2016-06-02
dc.date.updated2017-01-05T09:56:08Z
dc.description.abstractMultiple Sclerosis (MS), an idiopathic progressive immune-mediated neurological disorder of the central nervous system (CNS), is characterized by recurrent episodes of inflammatory demyelination and consequent axonal deterioration. It accounts for functional deterioration and lasting disability among young adults. A body of literature demonstrates that physical activity counteracts fatigue and depression and may improve overall quality of life in MS patients. Furthermore, much data indicates that exercise ameliorates chronic neuroinflammation and its related pathologies by tipping cytokine profiles toward an anti-inflammatory signature. Recent data has focused on the direct impact of exercise training on the innate immune system by targeting toll-like receptors (TLRs), signaling pattern recognition receptors that govern the innate immune response, shedding light on the physiological role of TLRs in health and disease. Indeed, TLRs continue to emerge as players in the neuroinflammatory processes underpinning MS. This review will highlight evidence that physical activity and exercise are potential immunomodulatory therapies, targeting innate signaling mechanism(s) to modulate MS symptom development and progression.en
dc.description.sponsorshipUniversity College Cork (Physiological Society, Department of Physiology); Trinity College Dublin (Department of Physiology)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBarry, A., Cronin, O., Ryan, A. M., Sweeney, B., Yap, S. M., O'Toole, O., Allen, A. P., Clarke, G., O'Halloran, K. D. and Downer, E. J. (2016) 'Impact of Exercise on Innate Immunity in Multiple Sclerosis Progression and Symptomatology', Frontiers in Physiology, 7,194 (13 pp). doi:10.3389/fphys.2016.00194en
dc.identifier.doi10.3389/fphys.2016.00194
dc.identifier.endpage194-13en
dc.identifier.issn1664-042X
dc.identifier.journaltitleFrontiers in Physiologyen
dc.identifier.startpage194-1en
dc.identifier.urihttps://hdl.handle.net/10468/3429
dc.identifier.volume7en
dc.language.isoenen
dc.publisherFrontiers Mediaen
dc.rights© 2016 Barry, Cronin, Ryan, Sweeney, Yap, O'Toole, Allen, Clarke, O'Halloran and Downer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectMultiple Sclerosisen
dc.subjectExerciseen
dc.subjectNeuroinflammationen
dc.subjectInnate immunityen
dc.subjectTLRsen
dc.subjectCytokinesen
dc.titleImpact of exercise on innate immunity in multiple sclerosis progression and symptomatologyen
dc.typeArticle (peer-reviewed)en
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