Multi-configuration Raman spectrometer for early stage diagnosis of oral cancer

Thumbnail Image
Siddra Maryam 2022.pdf(792.01 KB)
Published Version
Maryam, Siddra
Saito Nogueira, Marcelo
Krishna Moorthy, Shree
Sekar, Sanathana Konugolu Venkata
Lu, Huihui
Gautam, Rekha
Burke, Ray
Andersson-Engels, Stefan
Ni Riordain, Richeal
Sheahan, Patrick
Journal Title
Journal ISSN
Volume Title
Society of Photo-Optical Instrumentation Engineers (SPIE)
Published Version
Research Projects
Organizational Units
Journal Issue
Oral Squamous Cell carcinoma (OSCC) is one of the most common and aggressive oral malignancies. Despite all significant advances in medicine, five-year survival rate is still 40%-60%. Diagnosis in early stages is critical as it can improve the survival rate and the quality of life after treatment. This study aims to develop a strategy for diagnosing oral cancer non-invasively in the early stages and to provide better surgical guidance by differentiating healthy and tumor tissues by using Raman spectroscopy. For this purpose, a multimodal Raman system is developed to detect oral cancer biomarkers in patient’s saliva specimen and to study different tissue types in oral cavity with Raman spectroscopy. The developed system is quite compact, easy to use and portable. It can be easily modified for in vivo and ex vivo analysis and can work in both reflection and transmission mode in case of ex vivo measurements. This paper compares the surface enhancement and background spectra from different plasmonic nanoparticles. Lastly, bovine serum albumin (BSA) and uric acid were used as model analytes to at physiologically relevant concentrations to test the performance of the system.
Oral Squamous Cell carcinoma (OSCC) , Raman spectroscopy , Multimodal Raman system
Maryam, S., Saito Nogueira, M., Krishna Moorthy, S., Sekar, S., Lu, H., Gautam, R., Burke, R.,Andersson-Engels, S., Ni Riordain, R. and Sheahan, P. (2023) 'Multi-configuration Raman spectrometer for early stage diagnosis of oral cancer', Proceedings of SPIE, 11957, Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, 1195706 (7pp). doi: 10.1117/12.2610704
© 2023, Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.