Periconceptual and prenatal alcohol consumption and neurodevelopment at age two and five years

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dc.contributor.authorMaher, Gillian M.
dc.contributor.authorKhashan, Ali S.
dc.contributor.authorO'Byrne, Laura
dc.contributor.authorFlanagan, Sinead
dc.contributor.authorMortimer, Roisin .M.
dc.contributor.authorKiely Mairead
dc.contributor.authorHourihane, Jonathan O'B.
dc.contributor.authorKenny, Louise C.
dc.contributor.authorMurray, Deirdre M.
dc.contributor.authorMcCarthy, Fergus P.
dc.contributor.funderHealth Research Boarden
dc.contributor.funderNational Children's Research Centreen
dc.date.accessioned2022-07-20T15:23:01Z
dc.date.available2022-07-20T15:23:01Z
dc.date.issued2022-05-31
dc.date.updated2022-07-20T15:12:30Z
dc.description.abstractObjective: Examine the association between alcohol consumption before and during pregnancy and neurodevelopmental outcomes in the offspring at two and five years. Study design: Retrospective analysis of a prospective longitudinal cohort; SCOPE-BASELINE. Data on pre-conception and prenatal alcohol consumption were obtained at 15 weeks’ gestation and categorised as abstinent, occasional-low (1-7units/week) and moderate-heavy (≥8units/week). Binge drinking was defined as ≥6 units/session. Outcome measures (Child Behaviour Checklist and Kaufman Brief Intelligence Test) were obtained at two and five years. Linear regression examined an alcohol consumption and Child Behaviour Checklist and Kaufman Brief Intelligence Test relationship, adjusting for several potential confounders. Results: Data on alcohol consumption was available for 1,507 women. Adjusted linear regression suggested few associations: pre-pregnancy occasional-low alcohol consumption was associated with lower log externalizing Child Behaviour Checklist scores (-0.264, 95% CI: −0.009, −0.520), while pre-pregnancy moderate-high levels of alcohol consumption was associated with lower Kaufman Brief Intelligence Test verbal standard scores (-0.034, 95% CI: −0.001, −0.068) and composite IQ scores (-0.028, 95% CI: −0.056, −0.0004) at five-years. In the first trimester, moderate-high levels of alcohol consumption was associated with lower internalizing Child Behaviour Checklist scores at two-years (-0.252, 95% CI: −0.074, −0.430). No significant associations were observed between number of binge episodes pre-pregnancy or binge drinking in the first trimester and Child Behaviour Checklist or Kaufman Brief Intelligence Test. Conclusions: We did not find strong evidence of associations between pre-pregnancy and early pregnancy maternal alcohol consumption and adverse neurodevelopmental outcomes at age two and five years overall. Further research examining alcohol consumption (including binge drinking) beyond 15 weeks’ gestation and subsequent neurodevelopmental outcomes is needed to examine the potential effect of alcohol consumption in later pregnancy.en
dc.description.sponsorshipHealth Research Board (SCOPE Ireland Study HRB grant number CSA 02/2007)); National Children’s Research Centre, Ireland, NCRC (BASELINE 2008 and 2012)en
dc.description.statusPeer revieweden
dc.description.versionPublished Versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMaher, G. M., Khashan, A. S.; O’Byrne, L., Flanagan, S., Mortimer, R. M., Kiely M., Hourihane, J. O'B., Kenny, L. C., Murray, D., and McCarthy, F. P. (2022) 'Periconceptual and prenatal alcohol consumption and neurodevelopment at age two and five years’, European Journal of Obstetrics & Gynecology and Reproductive Biology, 274, pp. 197-203. doi: 10.1016/j.ejogrb.2022.05.034en
dc.identifier.doi10.1016/j.ejogrb.2022.05.034en
dc.identifier.endpage203en
dc.identifier.issn0301-2115
dc.identifier.journaltitleEuropean Journal of Obstetrics & Gynecology and Reproductive Biologyen
dc.identifier.startpage197en
dc.identifier.urihttps://hdl.handle.net/10468/13385
dc.identifier.volume274en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.projectSCOPE Ireland Study was supported by the Health Research Board, Ireland (grant number CSA 02/2007); BASELINE was funded by the National Children’s Research Centre (NCRC) in 2008 and 2012.en
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0301211522003724
dc.rights© 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAlcoholen
dc.subjectEpidemiologyen
dc.subjectNeurodevelopmenten
dc.titlePericonceptual and prenatal alcohol consumption and neurodevelopment at age two and five yearsen
dc.typeArticle (peer-reviewed)en
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