Hypertensive disorders of pregnancy and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis protocol

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dc.contributor.author Maher, Gillian M.
dc.contributor.author O'Keeffe, Gerard W.
dc.contributor.author Kenny, Louise C.
dc.contributor.author Kearney, Patricia M.
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Khashan, Ali S.
dc.date.accessioned 2017-12-08T13:33:43Z
dc.date.available 2017-12-08T13:33:43Z
dc.date.issued 2017-10-01
dc.identifier.citation Maher, G. M., O’Keeffe, G. W., Kenny, L. C., Kearney, P. M., Dinan, T. G. and Khashan, A. S. (2017) 'Hypertensive disorders of pregnancy and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis protocol', BMJ Open, 7(10), e018313 (6pp). doi:10.1136/bmjopen-2017-018313 en
dc.identifier.volume 7
dc.identifier.issued 10
dc.identifier.startpage 1
dc.identifier.endpage 6
dc.identifier.issn 2044-6055
dc.identifier.uri http://hdl.handle.net/10468/5142
dc.identifier.doi 10.1136/bmjopen-2017-018313
dc.description.abstract Introduction Hypertensive disorders of pregnancy (HDPs), that is chronic hypertension, gestational hypertension, pre-eclampsia (de novo or superimposed on chronic hypertension) and white coat hypertension, affect approximately 5%–15% of pregnancies. HDP exposure has been linked to an increased risk of autism spectrum disorder, attention deficit/hyperactivity disorder and other neurodevelopmental disorders in children. However, findings are inconsistent, and a clear consensus on the impact of HDPs on the risk of neurodevelopmental disorders is needed. Therefore, we aim to synthesise the published literature on the relationship between HDPs and the risk of neurodevelopmental disorders in the form of a systematic review and meta-analysis. Methods and analysis We will include cohort, case– control and cross-sectional studies in which diagnosis of an HDP was reported, and neurodevelopmental disorders were the outcome of interest based on a preprepared protocol. A systematic search of PubMed, CINAHL, Embase, PsycINFO and Web of Science will be conducted in accordance with a detailed search strategy. Two authors will independently review the titles and abstracts of all studies, perform data extraction using a standardised data collection form and assess study quality using a bias classification tool. Meta-analyses will be performed to calculate overall pooled estimates using the generic inverse variance method. This systematic review will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses. Ethics and dissemination This proposed systematic review and meta-analysis is based on published data, therefore, does not require ethics approval. Findings will be presented at scientific conferences and disseminated through publication in a peer-reviewed journal. Registration CRD42017068258. en
dc.description.sponsorship Health Research Board (SPHeRE (Structured Population and Health-services Research Education) en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher BMJ Publishing Group en
dc.relation.uri http://bmjopen.bmj.com/content/7/10/e018313
dc.rights © 2017, the Authors, unless otherwise stated in the text of the article. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ en
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.subject Hypertensive disorders of pregnancy en
dc.subject HDPs en
dc.subject Pregnancy en
dc.subject Neurodevelopmental disorders en
dc.title Hypertensive disorders of pregnancy and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis protocol en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Ali S. Khashan, Epidemiology and Public Health, University College Cork, Cork, Ireland. +353-21-490-3000 Email: a.khashan@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland
dc.contributor.funder Health Research Board
dc.description.status Peer reviewed en
dc.identifier.journaltitle BMJ Open en
dc.internal.IRISemailaddress a.khashan@ucc.ie en
dc.identifier.articleid e018313
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2272/IE/Irish Centre for Fetal and Neonatal Translational Research (INFANT)/
dc.relation.project info:eu-repo/grantAgreement/SFI/SFI Research Centres/12/RC/2273/IE/Alimentary Pharmabiotic Centre (APC) - Interfacing Food & Medicine/


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© 2017, the Authors, unless otherwise stated in the text of the article. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Except where otherwise noted, this item's license is described as © 2017, the Authors, unless otherwise stated in the text of the article. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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