A Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial

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dc.contributor.author Jennings, Amy
dc.contributor.author Cashman, Kevin D.
dc.contributor.author Gillings, Rachel
dc.contributor.author Cassidy, Aedin
dc.contributor.author Tang, Jonathan
dc.contributor.author Fraser, William
dc.contributor.author Dowling, Kirsten G.
dc.contributor.author Hull, George L. J.
dc.contributor.author Berendsen, Agnes A. M.
dc.contributor.author de Groot, Lisette C. P. G. M.
dc.contributor.author Pietruszka, Barbara
dc.contributor.author Wierzbicka, Elzbieta
dc.contributor.author Ostan, Rita
dc.contributor.author Bazzocchi, Alberto
dc.contributor.author Battista, Giuseppe
dc.contributor.author Caumon, Elodie
dc.contributor.author Meunier, Nathalie
dc.contributor.author Malpuech-Brugère, Corinne
dc.contributor.author Franceschi, Claudio
dc.contributor.author Santoro, Aurelia
dc.contributor.author Fairweather-Tait, Susan J.
dc.date.accessioned 2018-09-27T12:08:17Z
dc.date.available 2018-09-27T12:08:17Z
dc.date.issued 2018
dc.identifier.citation Jennings, A., Cashman, K. D., Gillings, R., Cassidy, A., Tang, J., Fraser, W., Dowling, K. G., Hull, G. L. J., Berendsen, A. A. M., de Groot, L. C. P. G. M., Pietruszka, B., Wierzbicka, E., Ostan, R., Bazzocchi, A., Battista, G., Caumon, E., Meunier, N., Malpuech-Brugère, C., Franceschi, C., Santoro, A. and Fairweather-Tait, S. J. (2018) 'A Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial', The American Journal of Clinical Nutrition, nqy122 (8pp). doi: 10.1093/ajcn/nqy122 en
dc.identifier.startpage 1
dc.identifier.endpage 8
dc.identifier.issn 0002-9165
dc.identifier.issn 1938-3207
dc.identifier.uri http://hdl.handle.net/10468/6932
dc.identifier.doi 10.1093/ajcn/nqy122
dc.description.abstract Background: The Mediterranean diet (MD) is widely recommended for the prevention of chronic disease, but evidence for a beneficial effect on bone health is lacking. Objective: The aim of this study was to examine the effect of a Mediterranean-like dietary pattern [NU-AGE (New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe)] on indexes of inflammation with a number of secondary endpoints, including bone mineral density (BMD) and biomarkers of bone and collagen degradation in a 1-y multicenter randomized controlled trial (RCT; NU-AGE) in elderly Europeans. Design: An RCT was undertaken across 5 European centers. Subjects in the intervention group consumed the NU-AGE diet for 1 y by receiving individually tailored dietary advice, coupled with supplies of foods including whole-grain pasta, olive oil, and a vitamin D3 supplement (10 µg/d). Participants in the control group were provided with leaflets on healthy eating available in their country. Results: A total of 1294 participants (mean ± SD age: 70.9 ±4.0 y; 44% male) were recruited to the study and 1142 completed the 1-y trial. The Mediterranean-like dietary pattern had no effect on BMD (site-specific or whole-body); the inclusion of compliance to the intervention in the statistical model did not change the findings. There was also no effect of the intervention on the urinary biomarkers free pyridinoline or free deoxypyridinoline. Serum 25-hydroxyvitamin D significantly increased and parathyroid hormone decreased (P < 0.001) in the MD compared with the control group. Subgroup analysis of individuals with osteoporosis at baseline (site-specific BMD T-score ≤ −2.5 SDs) showed that the MD attenuated the expected decline in femoral neck BMD (n = 24 and 30 in MD and control groups, respectively; P = 0.04) but had no effect on lumbar spine or whole-body BMD. Conclusions: A 1-y intervention of the Mediterranean-like diet together with vitamin D3 supplements (10 µg/d) had no effect on BMD in the normal age-related range, but it significantly reduced the rate of loss of bone at the femoral neck in individuals with osteoporosis. The NU-AGE trial is registered at clinicaltrials.gov as NCT01754012. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Oxford University Press en
dc.relation.uri https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqy122/5051862
dc.rights © 2018, American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com en
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.subject Osteoporosis en
dc.subject Bone en
dc.subject Mediterranean diet en
dc.subject Vitamin D supplementation en
dc.subject Older adults en
dc.title A Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Kevin D. Cashman, Food & Nutritional Sciences, University College Cork, Cork, Ireland. +353-21-490-3000 Email: k.cashman@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.description.status Peer reviewed en
dc.identifier.journaltitle American Journal of Clinical Nutrition en
dc.internal.IRISemailaddress k.cashman@ucc.ie en
dc.identifier.articleid nyq22


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© 2018, American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Except where otherwise noted, this item's license is described as © 2018, American Society for Nutrition. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
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