Age-dependent differences in pulmonary host responses in ARDS: A prospective observational cohort study

Show simple item record Schouten, Laura R. van Kaam, Anton H. Kohse, Franziska Veltkamp, Floor Bos, Lieuwe D. de Beer, Friso M. van Hooijdonk, Roosmarijn T. Horn, Janneke Straat, Marleen Witteveen, Esther Glas, Gerie J. Wieske, Luuk van Vught, Lonneke A. Wiewel, Maryse A. Ingelse, Sarah A. Cortjens, Bart van Woensel, Job B. Bos, Albert P. Walther, Thomas Schultz, Marcus J. Wösten-van Asperen, Roelie M. 2019-11-20T05:21:18Z 2019-11-20T05:21:18Z 2019-05-14
dc.identifier.citation Schouten, L.R., van Kaam, A.H., Kohse, F., Veltkamp, F., Bos, L.D., de Beer, F.M., van Hooijdonk, R.T., Horn, J., Straat, M., Witteveen, E. and Glas, G.J., 2019. Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. Annals of intensive care, 9(1), (55). DOI:10.1186/s13613-019-0529-4 en
dc.identifier.volume 9 en
dc.identifier.issued 1 en
dc.identifier.startpage 1 en
dc.identifier.endpage 9 en
dc.identifier.doi 10.1186/s13613-019-0529-4 en
dc.description.abstract Background: Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory distress syndrome (ARDS) between children and adults. The present study compares biomarkers of host defense and RAS in bronchoalveolar lavage (BAL) fluid from neonates, children, adults, and older adults with ARDS. Methods: In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age groups: 20 neonates (< 28 days corrected postnatal age), 29 children (28 days–18 years), 26 adults (18–65 years), and 17 older adults (> 65 years of age). All patients underwent a nondirected BAL within 72 h after intubation. Activities of the two main enzymes of RAS, angiotensin converting enzyme (ACE) and ACE2, and levels of biomarkers of inflammation, endothelial activation, and epithelial damage were determined in BAL fluid. Results: Levels of myeloperoxidase, interleukin (IL)-6, IL-10, and p-selectin were higher with increasing age, whereas intercellular adhesion molecule-1 was higher in neonates. No differences in activity of ACE and ACE2 were seen between the four age groups. Conclusions: Age-dependent differences in the levels of biomarkers in lungs of ARDS patients are present. Especially, higher levels of markers involved in the neutrophil response were found with increasing age. In contrast to preclinical studies, age is not associated with changes in the pulmonary RAS. en
dc.description.sponsorship 041-201 en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Open en
dc.rights © The Author(s) 2019 en
dc.rights.uri en
dc.subject ARDS en
dc.subject Angiotensin converting enzyme en
dc.subject Pathophysiology en
dc.subject Aging en
dc.subject Host response en
dc.subject Biomarkers en
dc.title Age-dependent differences in pulmonary host responses in ARDS: A prospective observational cohort study en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Thomas Walther, Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland. +353-21-490-3000 Email: en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Center for Translational Molecular Medicine en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Annals of Intensive Care en
dc.internal.IRISemailaddress en
dc.identifier.articleid 55 en
dc.relation.project Molecular Diagnosis and Risk stratification of Sepsis (MARS) en
dc.identifier.eissn 2110-5820

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