Age-dependent differences in pulmonary host responses in ARDS: A prospective observational cohort study

Show simple item record

dc.contributor.author Schouten, Laura R.
dc.contributor.author van Kaam, Anton H.
dc.contributor.author Kohse, Franziska
dc.contributor.author Veltkamp, Floor
dc.contributor.author Bos, Lieuwe D.
dc.contributor.author de Beer, Friso M.
dc.contributor.author van Hooijdonk, Roosmarijn T.
dc.contributor.author Horn, Janneke
dc.contributor.author Straat, Marleen
dc.contributor.author Witteveen, Esther
dc.contributor.author Glas, Gerie J.
dc.contributor.author Wieske, Luuk
dc.contributor.author van Vught, Lonneke A.
dc.contributor.author Wiewel, Maryse A.
dc.contributor.author Ingelse, Sarah A.
dc.contributor.author Cortjens, Bart
dc.contributor.author van Woensel, Job B.
dc.contributor.author Bos, Albert P.
dc.contributor.author Walther, Thomas
dc.contributor.author Schultz, Marcus J.
dc.contributor.author Wösten-van Asperen, Roelie M.
dc.date.accessioned 2019-11-20T05:21:18Z
dc.date.available 2019-11-20T05:21:18Z
dc.date.issued 2019-05-14
dc.identifier.citation Schouten, L.R., van Kaam, A.H., Kohse, F., Veltkamp, F., Bos, L.D., de Beer, F.M., van Hooijdonk, R.T., Horn, J., Straat, M., Witteveen, E. and Glas, G.J., 2019. Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. Annals of intensive care, 9(1), (55). DOI:10.1186/s13613-019-0529-4 en
dc.identifier.volume 9 en
dc.identifier.issued 1 en
dc.identifier.startpage 1 en
dc.identifier.endpage 9 en
dc.identifier.uri http://hdl.handle.net/10468/9115
dc.identifier.doi 10.1186/s13613-019-0529-4 en
dc.description.abstract Background: Results from preclinical studies suggest that age-dependent differences in host defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed differences in epidemiology of acute respiratory distress syndrome (ARDS) between children and adults. The present study compares biomarkers of host defense and RAS in bronchoalveolar lavage (BAL) fluid from neonates, children, adults, and older adults with ARDS. Methods: In this prospective observational study, we enrolled mechanical ventilated ARDS patients categorized into four age groups: 20 neonates (< 28 days corrected postnatal age), 29 children (28 days–18 years), 26 adults (18–65 years), and 17 older adults (> 65 years of age). All patients underwent a nondirected BAL within 72 h after intubation. Activities of the two main enzymes of RAS, angiotensin converting enzyme (ACE) and ACE2, and levels of biomarkers of inflammation, endothelial activation, and epithelial damage were determined in BAL fluid. Results: Levels of myeloperoxidase, interleukin (IL)-6, IL-10, and p-selectin were higher with increasing age, whereas intercellular adhesion molecule-1 was higher in neonates. No differences in activity of ACE and ACE2 were seen between the four age groups. Conclusions: Age-dependent differences in the levels of biomarkers in lungs of ARDS patients are present. Especially, higher levels of markers involved in the neutrophil response were found with increasing age. In contrast to preclinical studies, age is not associated with changes in the pulmonary RAS. en
dc.description.sponsorship 041-201 en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Springer Open en
dc.relation.uri https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-019-0529-4
dc.rights © The Author(s) 2019 en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject ARDS en
dc.subject Angiotensin converting enzyme en
dc.subject Pathophysiology en
dc.subject Aging en
dc.subject Host response en
dc.subject Biomarkers en
dc.title Age-dependent differences in pulmonary host responses in ARDS: A prospective observational cohort study en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Thomas Walther, Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland. +353-21-490-3000 Email: t.walther@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Center for Translational Molecular Medicine en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Annals of Intensive Care en
dc.internal.IRISemailaddress t.walther@ucc.ie en
dc.identifier.articleid 55 en
dc.relation.project Molecular Diagnosis and Risk stratification of Sepsis (MARS) en
dc.identifier.eissn 2110-5820


Files in this item

This item appears in the following Collection(s)

Show simple item record

© The Author(s) 2019 Except where otherwise noted, this item's license is described as © The Author(s) 2019
This website uses cookies. By using this website, you consent to the use of cookies in accordance with the UCC Privacy and Cookies Statement. For more information about cookies and how you can disable them, visit our Privacy and Cookies statement