Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: A map of the current evidence

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dc.contributor.author Krinzinger, Helga
dc.contributor.author Hall, Charlotte L.
dc.contributor.author Groom, Madeleine J.
dc.contributor.author Ansari, Mohammed T.
dc.contributor.author Banaschewski, Tobias
dc.contributor.author Buitelaar, Jan K.
dc.contributor.author Carucci, Sara
dc.contributor.author Coghill, David
dc.contributor.author Danckaerts, Marina
dc.contributor.author Dittmann, Ralf W.
dc.contributor.author Falissard, Bruno
dc.contributor.author Garas, Peter
dc.contributor.author Inglis K., Sarah K.
dc.contributor.author Kovshoff, Hanna
dc.contributor.author Kochhar, Puja
dc.contributor.author McCarthy, Suzanne
dc.contributor.author Nagy, Peter
dc.contributor.author Neubert, Antje
dc.contributor.author Roberts, Samantha
dc.contributor.author Sayal, Kapil
dc.contributor.author Sonuga-Barke, Edmund
dc.contributor.author Wong, Ian C. K.
dc.contributor.author Xia, Jun
dc.contributor.author Zuddas, Alessandro
dc.contributor.author Hollis, Chris
dc.contributor.author Konrad, Kerstin
dc.contributor.author Liddle, Elizabeth B.
dc.date.accessioned 2019-12-09T10:14:55Z
dc.date.available 2019-12-09T10:14:55Z
dc.date.issued 2019-09-20
dc.identifier.citation Krinzinger, H., Hall, C. L., Groom, M. J., Ansari, M. T., Banaschewski, T., Buitelaar, J. K., Carucci, S., Coghill, D., Danckaerts, M., Dittmann, R. W., Falissard, B., Garas, P., Inglis, S. K., Kovshoff, H., Kochhar, P., McCarthy, S., Nagy, P., Neubert, A., Roberts, S., Sayal, K., Sonuga-Barke, E., Wong, I. C. K., Xia, J., Zuddas, A., Hollis, C., Konrad, K. and Liddle, E. B. (2019) 'Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: A map of the current evidence', Neuroscience & Biobehavioral Reviews, 107, pp. 945-968. doi: 10.1016/j.neubiorev.2019.09.023 en
dc.identifier.volume 107 en
dc.identifier.startpage 945 en
dc.identifier.endpage 968 en
dc.identifier.issn 0149-7634
dc.identifier.uri http://hdl.handle.net/10468/9354
dc.identifier.doi 10.1016/j.neubiorev.2019.09.023 en
dc.description.abstract Methylphenidate (MPH), the most common medication for children with Attention Deficit/Hyperactivity Disorder (ADHD) in many countries, is often prescribed for long periods of time. Any long-term psychotropic treatment in childhood raises concerns about possible adverse neurological and psychiatric outcomes. We aimed to map current evidence regarding neurological and psychiatric outcomes, adverse or beneficial, of long-term MPH (> 1 year) treatment in ADHD. We coded studies using a “traffic light” system: Green: safe/favours MPH; Amber: warrants caution; Red: not safe/not well-tolerated. Un-categorisable study findings were coded as “Unclear”. Although some evidence suggests an elevated risk of psychosis and tics, case reports describe remission on discontinuation. Several studies suggest that long-term MPH may reduce depression and suicide in ADHD. Evidence suggests caution in specific groups including pre-school children, those with tics, and adolescents at risk for substance misuse. We identified a need for more studies that make use of large longitudinal databases, focus on specific neuropsychiatric outcomes, and compare outcomes from long-term MPH treatment with outcomes following shorter or no pharmacological intervention. en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher Elsevier Ltd en
dc.rights ©2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).T en
dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0/ en
dc.subject Long-term methylphenidate treatment en
dc.subject ADHD en
dc.subject Adverse neuropsychiatric events en
dc.subject Mood en
dc.subject Anxiety en
dc.subject Suicidal ideation en
dc.subject Bipolar en
dc.subject Psychosis en
dc.subject Substance use disorder en
dc.subject Tics en
dc.subject Seizures en
dc.subject Sleep disorders en
dc.title Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: A map of the current evidence en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Suzanne McCarthy, School of Pharmacy, University College Cork, Cork, Ireland. +353-21-490-3000 Email:s.mccarthy@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Seventh Framework Programme en
dc.contributor.funder NIHR Imperial Biomedical Research Centre en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Neuroscience and Biobehavioral Reviews en
dc.internal.IRISemailaddress s.mccarthy@ucc.ie en
dc.relation.project info:eu-repo/grantAgreement/EC/FP7::SP1::HEALTH/260576/EU/Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects/ADDUCE en
dc.identifier.eissn 1873-7528


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©2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).T Except where otherwise noted, this item's license is described as ©2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).T
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