Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: A map of the current evidence
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Date
2019-09-20
Authors
Krinzinger, Helga
Hall, Charlotte L.
Groom, Madeleine J.
Ansari, Mohammed T.
Banaschewski, Tobias
Buitelaar, Jan K.
Carucci, Sara
Coghill, David
Danckaerts, Marina
Dittmann, Ralf W.
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Publisher
Elsevier Ltd
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Abstract
Methylphenidate (MPH), the most common medication for children with Attention Deficit/Hyperactivity Disorder (ADHD) in many countries, is often prescribed for long periods of time. Any long-term psychotropic treatment in childhood raises concerns about possible adverse neurological and psychiatric outcomes. We aimed to map current evidence regarding neurological and psychiatric outcomes, adverse or beneficial, of long-term MPH (> 1 year) treatment in ADHD. We coded studies using a “traffic light” system: Green: safe/favours MPH; Amber: warrants caution; Red: not safe/not well-tolerated. Un-categorisable study findings were coded as “Unclear”. Although some evidence suggests an elevated risk of psychosis and tics, case reports describe remission on discontinuation. Several studies suggest that long-term MPH may reduce depression and suicide in ADHD. Evidence suggests caution in specific groups including pre-school children, those with tics, and adolescents at risk for substance misuse. We identified a need for more studies that make use of large longitudinal databases, focus on specific neuropsychiatric outcomes, and compare outcomes from long-term MPH treatment with outcomes following shorter or no pharmacological intervention.
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Keywords
Long-term methylphenidate treatment , ADHD , Adverse neuropsychiatric events , Mood , Anxiety , Suicidal ideation , Bipolar , Psychosis , Substance use disorder , Tics , Seizures , Sleep disorders
Citation
Krinzinger, H., Hall, C. L., Groom, M. J., Ansari, M. T., Banaschewski, T., Buitelaar, J. K., Carucci, S., Coghill, D., Danckaerts, M., Dittmann, R. W., Falissard, B., Garas, P., Inglis, S. K., Kovshoff, H., Kochhar, P., McCarthy, S., Nagy, P., Neubert, A., Roberts, S., Sayal, K., Sonuga-Barke, E., Wong, I. C. K., Xia, J., Zuddas, A., Hollis, C., Konrad, K. and Liddle, E. B. (2019) 'Neurological and psychiatric adverse effects of long-term methylphenidate treatment in ADHD: A map of the current evidence', Neuroscience & Biobehavioral Reviews, 107, pp. 945-968. doi: 10.1016/j.neubiorev.2019.09.023